In vitro pharmacological evaluation of Methanolic leaf extract of Calotropis procera for antifungal and anti-breast cancer activities.
| Autor: | Rasool S; Department of Eastern Medicine, Government College University Faisalabad, Allama Iqbal Road, Faisalabad, Pakistan., Rashid A; Faculty of Medical Sciences, Government College University Faisalabad, Allama Iqbal Road, Faisalabad, Pakistan., Akram M; Department of Eastern Medicine, Government College University Faisalabad, Allama Iqbal Road, Faisalabad, Pakistan., Sierra FG; Department of Cell Biology, Center for Research and Applied Studies of Polytechnic Institute, Mexico. |
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| Jazyk: | angličtina |
| Zdroj: | Toxicology research [Toxicol Res (Camb)] 2024 Nov 11; Vol. 13 (6), pp. tfae186. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024). |
| DOI: | 10.1093/toxres/tfae186 |
| Abstrakt: | Background: Medicinal plants remained the primary choice worldwide from several centuries due to many therapeutic effects in the management of infectious and non-infectious diseases. Therefore, exploration of new medicinalplants as a green medicine has the major concern of many research groups. Microbial infections and different types of cancers in human are among the common health problems both in developing as well as in developed countries. Medicinal plants as a source of anti-microbial and anti-cancer agents are still in their initial stage in modern medicine. Objectives: So current research work was planned to explore the anti-fungal and anticancer potential of Calotropis procera . Material and Methods: C. procera leaves were collected from local area of Faisalabad, Pakistan, and phytochemical, anti-microbial, and anti-cancer activities were studied following reference methods. In vitro anti-microbial study of methanolic extracts of C. procera leaves against different strains of fungal was performed. Results: Results showed that plant extract in a dose of 5 mg/mL have significant ( P < 0.05) antifungal activity. Moreover, the methanolic leaf extract of C. procera displayed strong anti-cancer activity in breast cancer cells (MCF-7), with a cytotoxic activityat 200 μg/mL comparable to that found for Taxol as standard drug. Conclusion: Findings of current research work showed that the leaf extracts of C. procera has strong potential as an antibacterial, antifungal and anti-cancer agent. However, characterization and purification of phytochemicals is required to develop drug from natural resources. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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