Diffusion-Weighted Imaging Does Not Differentiate Between Bacterial and Fungal Skull Base Osteomyelitis.

Autor: Karthat AG; Department of Otolaryngology, Christian Medical College, Vellore, India., Regi S; Department of Radiology, Christian Medical College, Vellore, India., Thomas H; Department of Otolaryngology, Christian Medical College, Vellore, India., Sara KB; Department of Otolaryngology, Christian Medical College, Vellore, India., Beula Subashini P; Department of Microbiology, Christian Medical College, Vellore, India., Sundaresan R; Department of Otolaryngology, Christian Medical College, Vellore, India., Thomas R; Department of Otolaryngology, Christian Medical College, Vellore, India.
Jazyk: angličtina
Zdroj: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery [Clin Otolaryngol] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1111/coa.14256
Abstrakt: Objective: Apparent diffusion coefficient (ADC) value helps in differentiating infections from neoplasms on magnetic resonance imaging (MRI). We investigate the diffusion-weighted images in skull base osteomyelitis (SBO) to evaluate if ADC values can differentiate fungal and bacterial SBO and to analyse the microbiology of all SBO patients.
Design: Retrospective observational study.
Setting: Quaternary care referral centre.
Participants: A retrospective review of 142 patients diagnosed and treated for SBO patients from January 2010 to May 2023 was done.
Main Outcome Measure: Chi-square or Fisher's exact test was used to compare ADC values of bacterial and fungal SBO.
Results: The most common pathogens isolated were Pseudomonas (42.2%), Aspergillus (30.98%), and S. aureus (23.94%). The average ADC value of affected soft tissues among patients was 1.13 ± 0.26 × 10 -3  mm2/s compared to the average ADC value of normal soft tissue, 1.34 ± 0.31 × 10 -3  mm2/s. There was no statistical significance when comparing the average ADC values of bacterial and fungal SBO patients (p value = 0.142).
Conclusion: This study suggests that though infection due to Pseudomonas was the commonest, it was detected only in 42.2% of patients. More than half of the cases had organisms other than Pseudomonas, demanding the clinician to obtain deeper biopsies early in the course of the disease for microbiological analysis. DWI does not help differentiate bacterial and fungal SBO, again emphasising the need for deeper tissue biopsies in all these patients to assist in the early identification of the pathogen.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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