Retinal vascular events and relationship to CANCER development.

Autor: Ortega-Toledo P; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain., Rodríguez-Gaspar MÁ; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain; Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, Spain., Barrios-Padilla IC; Grado en Medicina, Facultad de Ciencias de La Salud, Universidad de La Laguna, Spain., Mantolán-Sarmiento C; Servicio de Oftalmología, Hospital Universitario de Canarias, Spain., de La Paz-Estrello AM; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain., Fernández-Alonso P; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain., Pérez-Hernández O; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain., Martín-González C; Servicio de Medicina Interna, Hospital Universitario de Canarias, Spain; Departamento de Medicina Interna, Dermatología y Psiquiatría, Universidad de La Laguna, Spain. Electronic address: mmartgon@ull.edu.es.
Jazyk: angličtina
Zdroj: Thrombosis research [Thromb Res] 2024 Dec; Vol. 244, pp. 109207. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1016/j.thromres.2024.109207
Abstrakt: Background: Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal venous thrombosis and their relationship with the development of cancer.
Methods: 710 patients with retinal vascular pathology were included, of whom 527 had suffered retinal venous thrombosis. Patients were followed up in internal medicine outpatient clinics between September 24, 1999, and April 30, 2022. The incidence of cancer during that time was collected.
Results: Of 527 patients evaluated, 448 (86.7 %) presented cardiovascular risk factors, and 89 (17.2 %) developed some neoplasm, being the most frequent: prostate (19.1 %), colon (16.9 %), skin (12.4 %), breast (9.0 %). Retinal venous thrombosis was related to the development of neoplasms during follow-up time (Log Rank = 5.28, p = 0.022; Breslow = 4.84, p = 0.028). Other significant factors were age above the median, smoking, HbA1c levels, and homocysteine levels higher than the median, and cholesterol and LDL-Cholesterol lower than the median. Age above the median (p < 0.001), smoking (p = 0.003) and levels of cholesterol below the median (p = 0.026) were independently related to the development of neoplasms.
Conclusions: Retinal venous thrombosis is associated with the development of cancer. Other factors related to its development have been identified. If this is confirmed, the implications for the diagnosis, control, and treatment of these patients should be evaluated.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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