Hierarchical behavior control by a single class of interneurons.

Autor:	Huo J; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Department of Histology and Embryology, School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China., Xu T; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Deep Space Exploration Laboratory, Hefei 230088, China.; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China., Liu Q; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China., Polat M; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China., Kumar S; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540., Zhang X; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China., Leifer AM; Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540.; Department of Physics, Princeton University, Princeton, NJ 08540., Wen Q; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.; Deep Space Exploration Laboratory, Hefei 230088, China.; Center for Integrative Imaging, Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230026, China.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Nov 19; Vol. 121 (47), pp. e2410789121. Date of Electronic Publication: 2024 Nov 12.
DOI:	10.1073/pnas.2410789121
Abstrakt:	Animal behavior is organized into nested temporal patterns that span multiple timescales. This behavior hierarchy is believed to arise from a hierarchical neural architecture: Neurons near the top of the hierarchy are involved in planning, selecting, initiating, and maintaining motor programs, whereas those near the bottom of the hierarchy act in concert to produce fine spatiotemporal motor activity. In Caenorhabditis elegans , behavior on a long timescale emerges from ordered and flexible transitions between different behavioral states, such as forward, reversal, and turn. On a short timescale, different parts of the animal body coordinate fast rhythmic bending sequences to produce directional movements. Here, we show that Sublateral Anterior A (SAA), a class of interneurons that enable cross-communication between dorsal and ventral head motor neurons, play a dual role in shaping behavioral dynamics on different timescales. On a short timescale, SAA regulate and stabilize rhythmic bending activity during forward movements. On a long timescale, the same neurons suppress spontaneous reversals and facilitate reversal termination by inhibiting Ring Interneuron M (RIM), an integrating neuron that helps maintain a behavioral state. These results suggest that feedback from a lower-level cell assembly to a higher-level command center is essential for bridging behavioral dynamics at different levels. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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