Association between systemic immunity-inflammation index and glucose regulation in non-diabetic population: A population-based study from the NHANES (2005-2016).

Autor: Qing W; Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China., Qian Y; Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Nov 12; Vol. 19 (11), pp. e0313488. Date of Electronic Publication: 2024 Nov 12 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0313488
Abstrakt: Background: To investigated the link between the systemic immunity-inflammation index (SII), a new inflammatory biomarker, and the risk of abnormal glucose regulation in non-diabetic population.
Methods: Using data from the 2005-2016 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional study on non-diabetic adults with data on SII and glucose regulation markers. We analyzed the relationship between SII and indicators of glucose regulation, including fasting plasma glucose, fasting insulin, hemoglobin A1c, oral glucose tolerance test (OGTT), and states of abnormal glucose regulation like impaired glucose tolerance (IGT), insulin resistance, and prediabetes.
Results: Adjusting for confounders, higher SII levels were significantly associated with a higher OGTT and a greater likelihood of IGT (OR = 2.673, 95% CI: 1.845, 3.873). In subgroup analysis, participants without hyperlipidemia in the highest SII quartile had a 240% higher odds of IGT compared to those in the lowest quartile (OR = 3.407, 95%CI: 1.995, 5.820), an association not observed in those with hyperlipidemia (p for interaction < 0.05).
Conclusions: SII emerges as a useful biomarker for identifying IGT in non-diabetic individuals, specifically in those without hyperlipidemia.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Qing, Qian. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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