Harnessing the Anti-Inflammatory Effects of Perinatal Tissue Derived Therapies for the Treatment of Inflammatory Skin Diseases: A Comprehensive Review.

Autor: Khalilzad MA; Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 143951561, Iran.; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.; School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohammadi J; Department of Life Sciences Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 143951561, Iran. Javad.mohammadi@ut.ac.ir., Najafi S; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran., Amirsaadat S; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Zare S; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran. dr.sonazare@gmail.com.; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. dr.sonazare@gmail.com.; Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, Iran. dr.sonazare@gmail.com.; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. dr.sonazare@gmail.com., Khalilzad M; Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shamloo A; Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran. shamloo@sharif.edu., Khaghani A; Department of Gynecological Surgery, Tehranpars Hospital, Tehran, Iran., Peyrovan A; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran., Khalili SFS; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran., Fayyaz N; Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran., Zare S; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Stem cell reviews and reports [Stem Cell Rev Rep] 2024 Nov 12. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1007/s12015-024-10822-3
Abstrakt: Dealing with chronic inflammatory skin conditions like atopic dermatitis and psoriasis can be extremely difficult. Current treatments, such as topical corticosteroids, often have limitations and side effects. However, researchers have discovered that the placenta's remarkable properties may provide a breakthrough in effectively addressing these skin conditions. The placenta comprises three essential tissues: decidua, placental membrane, and umbilical cord. Placental derivatives have shown significant potential in treating psoriasis by reducing inflammatory cytokines and inhibiting keratinocyte proliferation. In the case of atopic dermatitis, umbilical cord stem cells have demonstrated anti-inflammatory effects by targeting critical factors and promoting anti-inflammatory cytokines. The scope of benefits associated with placental derivatives transcends these specific applications. They also potentially address other inflammatory skin diseases, such as vitiligo, by stimulating melanin production. Moreover, these derivatives have been leveraged in the treatment of pemphigus and epidermolysis bullosa (EB), showcasing potential as a wound dressing that could eliminate the necessity for painful dressing changes in EB patients. In summary, the integration of placental derivatives stands to revolutionize our approach to inflammatory skin conditions owing to their distinct properties and the prospective benefits they offer. This comprehensive review delves into the current applications of placental derivatives in addressing inflammatory skin diseases, presenting a novel treatment approach.
Competing Interests: Declarations Competing Interests The authors have no conflict of interest to declare. Ethical Approval not applicable.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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