Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.

Autor: Chen F; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Zhou D; School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China., Kong AP; Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China., Yim NT; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong SAR, China., Dai S; Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China. daisiyu@hznu.edu.cn.; School of Clinical Medicine, Hangzhou Normal University, Hangzhou, China. daisiyu@hznu.edu.cn.; The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China. daisiyu@hznu.edu.cn., Chen YN; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong SAR, China., Hui LL; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong SAR, China. connie.hui@polyu.edu.hk.; Research Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong, China. connie.hui@polyu.edu.hk.
Jazyk: angličtina
Zdroj: Current diabetes reports [Curr Diab Rep] 2024 Nov 12; Vol. 25 (1), pp. 4. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1007/s11892-024-01557-z
Abstrakt: Purpose of Review: Supplementation of nicotinamide mononucleotides (NMN) has been claimed to improve metabolic function. We reviewed human randomised controlled trials (RCTs) of NMN to evaluate its effect on markers of glucose and lipid metabolism.
Recent Findings: Eight RCTs on NMN (dosage ranged 250-2000 mg/d for a duration of 14 days to 12 weeks) involving a total of 342 middle-age/older adults (49% females, mainly non-diabetic) reporting at least one outcome on glucose control or lipid profile published in 2021-2023 were reviewed. The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile. Based on the small number of RCTs involving mainly relatively healthy adults, short-term supplementation of NMN of 250-2000 mg/d did not show significantly positive impacts on glucose control and lipid profile.
Competing Interests: Declarations Competing Interest One of our co-authors Prof Alice Pik Shan KONG is one of section editors for section entitled "Lifestyle and Team Based Management in People with Cardiovascular Risk" in Current Diabetes Reports. Human and Animal Rights and Informed Consent This article does not contain any studies with human or animal subjects performed by any of the authors.
(© 2024. The Author(s).)
Databáze: MEDLINE
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