Ecological and Reproductive Cycles Drive Henipavirus Seroprevalence in the African Straw-Coloured Fruit Bat ( Eidolon helvum ).

Autor: Juman MM; Department of Veterinary Medicine University of Cambridge Cambridge UK., Gibson L; Institute of Zoology Zoological Society of London London UK., Suu-Ire RD; School of Veterinary Medicine, College of Basic and Applied Sciences University of Ghana Accra Ghana., Languon S; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences University of Ghana Accra Ghana., Quaye O; West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences University of Ghana Accra Ghana., Fleischer G; School of Veterinary Medicine, College of Basic and Applied Sciences University of Ghana Accra Ghana., Asumah S; Wildlife Division of Forestry Commission Accra Ghana., Jolma ER; Department of Coastal Systems NIOZ Royal Netherlands Institute for Sea Research Yerseke The Netherlands.; Department of Population Health Sciences, Veterinary Medicine Utrecht University Utrecht The Netherlands., Gautam A; DST-CIMS, Institute of Science Banaras Hindu University Varanasi India., Sterling SL; Uniformed Services University of the Health Sciences Bethesda Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda Maryland USA., Yan L; Uniformed Services University of the Health Sciences Bethesda Maryland USA.; Henry M. Jackson Foundation for the Advancement of Military Medicine Bethesda Maryland USA., Broder CC; Uniformed Services University of the Health Sciences Bethesda Maryland USA., Laing ED; Uniformed Services University of the Health Sciences Bethesda Maryland USA., Wood JLN; Department of Veterinary Medicine University of Cambridge Cambridge UK., Cunningham AA; Institute of Zoology Zoological Society of London London UK., Restif O; Department of Veterinary Medicine University of Cambridge Cambridge UK.
Jazyk: angličtina
Zdroj: Ecology and evolution [Ecol Evol] 2024 Nov 11; Vol. 14 (11), pp. e70555. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024).
DOI: 10.1002/ece3.70555
Abstrakt: Bats are known to host zoonotic viruses, including henipaviruses that cause high fatality rates in humans (Nipah virus and Hendra virus). However, the determinants of zoonotic spillover are generally unknown, as the ecological and demographic drivers of viral circulation in bats are difficult to ascertain without longitudinal data. Here we analyse serological data collected from African straw-coloured fruit bats ( Eidolon helvum ) in Ghana over the course of 2 years and across four sites, comprising three wild roosts and one captive colony. We focus on antibody affinity to five henipavirus antigens: Ghanaian bat henipavirus (GhV), Nipah virus (NiV), Hendra virus (HeV), Mojiang virus (MojV) and Cedar virus (CedV). In the wild roosts, we detected seasonal variations in henipavirus antibody binding, possibly associated with bat life-history cycles and migration patterns. In the captive colony, we identified increases in antibody affinity levels among pregnant bats, suggesting possible shifts in the immune system during pregnancy. These bats then pass maternal antibodies to their pups, which wane before antibody affinity levels rise later in life following initial infections and/or reactivation of latent infections. These results improve our understanding of the links between bat ecology and viral circulation, including for GhV, a locally-circulating African henipavirus.
Competing Interests: The authors declare no conflicts of interest.
(© 2024 The Author(s). Ecology and Evolution published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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