Trends and patterns in pulmonary arterial hypertension-associated hospital admissions among methamphetamine users: a decade-long study.

Autor:	Husein A; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Boullion J; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Hossain MI; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Xing D; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Khan MTF; Department of Mathematics and Statistics, Cleveland State University, Cleveland, OH, United States., Bhuiyan MS; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Kolluru GK; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Bhuiyan MMR; Department of Pediatric Cardiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh., Goeders NE; Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Psychiatry and Behavioral Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Conrad SA; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pediatrics, LSU Health Sciences Center Shreveport, Shreveport, LA, United States., Vanchiere JA; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pediatrics, LSU Health Sciences Center Shreveport, Shreveport, LA, United States., Orr AW; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Kevil CG; Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States., Bhuiyan MAN; Department of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.; Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Oct 28; Vol. 11, pp. 1445193. Date of Electronic Publication: 2024 Oct 28 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1445193
Abstrakt:	Background: Pulmonary arterial hypertension (PAH) is a rare, chronic, progressive form of pulmonary hypertension in which increased arterial pressure causes remodeling of the arterial system and is associated with heart failure. Methamphetamine is a stimulant that has recently become a focus in PAH research, but the recent trends and demographics of this cohort of patients are not known. The study aimed to analyze the overall trends and demographics of PAH patients with and without concurrent methamphetamine usage. Methods: The study used the National Inpatient Sample (NIS), Healthcare Cost and Utilization Project (HCUP), and Agency for Healthcare Research and Quality (AHRQ) from 2008 to 2020 to calculate nationally weighted estimates for both conditions by ICD-9 and ICD-10 diagnosis codes. We used several statistical measures, including descriptive statistics with design-based chi-square and t -tests, trend analysis with Cochran-Armitage test, generalized linear models, and other data preprocessing measures. Results: A significant increase was evident in patients with pulmonary arterial hypertension (PAH) and concurrent methamphetamine use (9.2-fold). Most of the hospitalized patients were males (59.16%), aged 41-64 (45.77%), White (68.64%), from the West (53.09%), with Medicaid (50.48%), and with median income <$25,000. The rate of increase over the period was higher for males (11.8-fold), race (not sure which race; please check and modify), aged 41-64 (11.3-fold), and in the South (15.1-fold). An overall adjusted prevalence ratio (PR) for PAH hospitalizations among concurrent methamphetamine users was 32.19 (CI = 31.19-33.22) compared to non-users. With respective reference categories, the significantly higher PR was evident for males, patients aged 41-64, White, with Medicare, median income <$25,000, all regions compared to Northeast, length of hospital stays, and conditions, including chronic pulmonary disease, diabetes, hypertension, obesity, and peripheral vascular disorders. Conclusion: This study reveals a national overall and demographic-specific trend of increasing PAH with concurrent methamphetamine usage and associated factors. The findings may help to understand the current patterns and identify the vulnerable sociodemographic cohorts for further research and to take appropriate policy measures. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Husein, Boullion, Hossain, Xing, Khan, Bhuiyan, Kolluru, Bhuiyan, Goeders, Conrad, Vanchiere, Orr, Kevil and Bhuiyan.)
Databáze:	MEDLINE
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