Preoperative total parathyroid volume is an independent marker to predict recurrence for secondary hyperparathyroidism.
| Autor: | Wang Z; Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head& Neck Cancer, Tianjin, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin, China.; Department of General Surgery, Tianjin Third Central Hospital, Tianjin, China., Zhang F; Department of General Surgery, Tianjin Third Central Hospital, Tianjin, China., Zhu C; Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wu C; Department of General Surgery, Tianjin Third Central Hospital, Tianjin, China., Meng X; Department of General Surgery, Tianjin Third Central Hospital, Tianjin, China., Wang X; Department of Maxillofacial and Otorhinolaryngology Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Basic and Translational Medicine on Head& Neck Cancer, Tianjin, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin, China. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of medicine [Ann Med] 2024 Dec; Vol. 56 (1), pp. 2428435. Date of Electronic Publication: 2024 Nov 12. |
| DOI: | 10.1080/07853890.2024.2428435 |
| Abstrakt: | Purpose: This study aimed to explore the value of preoperative total parathyroid volume (TPV) as a marker for predict recurrence of renal secondary hyperparathyroidism (SHPT). Methods: We identified 28 patients with recurrence and 128 without recurrence who underwent total parathyroidectomy with autotransplantation (tPTX + AT) at our institution between 2015 and 2022. The TPV and postoperative recurrence information of the patients were recorded. Within the intergroup comparison, data obtained from the recurrence and non-recurrence groups were evaluated using the t-test. Univariate and multivariate analyses were performed according to the regression model to determine factors that were significant in predicting postoperative recurrence. The cutoff value of TPV was determined using a receiver operating characteristic (ROC) curve. Results: The mean TPV of recurrence and no-recurrence groups were 2.99 ± 1.52 cm 3 and 1.73 ± 1.19 cm 3 , respectively ( p = 0.007). In univariate analysis, female sex, total parathyroid volume > 1.99 cm 3 , serum PTH > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. In multivariable analysis, TPV > 1.99 cm 3 , serum parathyroid hormone (PTH) > 928.37 pg/mL and p > 1.59 mmol/L were independent factors for SHPT recurrence. The ability of TPV to distinguish between recurrence and non-recurrence was evaluated using the ROC curve. The cutoff value of TPV was estimated as 2.65 cm 3 . With this value, sensitivity was found as 60.70%, specificity was 89.80%, and AUC was 0.80 ( p < 0.001, confidence interval =0.719-0.882). Conclusion: According to the data in this study, it can be said that TPV can be used to distinguish recurrence from no-recurrence. Most importantly, TPV can be used to identify SHPT recurrence. |
| Databáze: | MEDLINE |
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