Brain neurovascular coupling in amyotrophic lateral sclerosis: Correlations with disease progression and cognitive impairment.

Autor: Trojsi F; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Canna A; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada., Sharbafshaaer M; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., di Nardo F; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Canale F; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Passaniti C; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Pirozzi MA; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Silvestro M; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Orologio I; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Russo A; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Cirillo M; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy., Tessitore A; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; First Division of Neurology and Neurophysiopathology, AOU Università degli Studi della Campania 'Luigi Vanvitelli', Naples, Italy., Siciliano M; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.; Department of Psychology, Università degli Studi della Campania 'Luigi Vanvitelli', Caserta, Italy.; Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St George's, University of London, London, UK., Esposito F; Department of Advanced Medical and Surgical Sciences, MRI Research Center, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2025 Jan; Vol. 32 (1), pp. e16540. Date of Electronic Publication: 2024 Nov 11.
DOI: 10.1111/ene.16540
Abstrakt: Background and Purpose: 'Neurovascular coupling' (NVC) alterations, assessing the interplay between local cerebral perfusion and neural activity within a given brain region or network, may reflect neurovascular unit impairment in amyotrophic lateral sclerosis (ALS). The aim was to explore NVC as a correlation between the functional connectivity and cerebral blood flow within the large-scale resting-state functional magnetic resonance imaging brain networks in a sample of ALS patients compared to healthy controls (HCs).
Methods: Forty-eight ALS patients (30 males; mean age 60.64 ± 9.62 years) and 32 HC subjects (14 males; mean age 55.06 ± 16 years) were enrolled and underwent 3 T magnetic resonance imaging. ALS patients were screened by clinical and neuropsychological scales and were retrospectively classified as very fast progressors (VFPs), fast progressors and slow progressors (SPs).
Results: Neurovascular coupling reduction within the default mode network (DMN) (p = 0.005) was revealed in ALS patients compared to HCs, observing, for this network, significant NVC differences between VFP and SP groups. Receiver operating characteristic curve analysis showed that impaired NVC in the DMN at baseline best discriminated VFPs and SPs (area under the curve 75%). Significant correlations were found between NVC and the executive (r = 0.40, p = 0.01), memory (r = 0.32, p = 0.04), visuospatial ability (r = 0.40, p = 0.01) and non-ALS-specific (r = 0.40, p = 0.01) subscores of the Edinburgh Cognitive and Behavioural ALS Screen.
Conclusions: The reduction of brain NVC in the DMN may reflect largely distributed abnormalities of the neurovascular unit. NVC alterations in the DMN could play a role in anticipating a faster clinical progression in ALS patients, aiding patient selection and monitoring during clinical trials.
(© 2024 The Author(s). European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.)
Databáze: MEDLINE
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