Celiac disease autoimmunity among Nigerian children and adolescents with type 1 diabetes mellitus.

Autor: Senbanjo IO; Department of Paediatrics and Child Health, Lagos State University College of Medicine, PMB 21266, Ikeja, Lagos, Lagos, Nigeria. senbanjo001@yahoo.com., Abolurin OO; Department of Paediatrics, Babcock University Teaching Hospital, Ilishan-Remo, Nigeria., Adekoya AO; Department of Paediatrics, Babcock University Teaching Hospital, Ilishan-Remo, Nigeria., Akinola IJ; Department of Paediatrics and Child Health, Lagos State University College of Medicine, PMB 21266, Ikeja, Lagos, Lagos, Nigeria., Anyabolu CH; Department of Paediatrics, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria., Adeniyi OF; Department of Paediatrics, College of Medicine, University of Lagos, Akoka, Lagos, Nigeria., Adepoju AA; Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ashubu OO; Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Gwarzo GD; Department of Paediatrics, Aminu Kano University Teaching Hospital, Kano, Nigeria.; Department of Paediatrics, College of Medical Sciences, Abubakar Tafawa Balewa University/Teaching Hospital, Bauchi, Nigeria., Bashir MF; Department of Paediatrics, College of Medical Sciences, Abubakar Tafawa Balewa University/Teaching Hospital, Bauchi, Nigeria., Umar UI; Department of Paediatrics, Aminu Kano University Teaching Hospital, Kano, Nigeria., Olorunmoteni OE; Department of Paediatrics, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria., Ugowe OJ; Department of Paediatrics, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria., Suwaid S; Department of Paediatrics, Murtala Mohammed Specialist Hospital, Kano, Nigeria., Sanni DA; Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Fetuga MB; Department of Paediatrics, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Nigeria., Oduwole AO; Department of Paediatrics, College of Medicine, University of Lagos, Akoka, Lagos, Nigeria.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2024 Nov 11; Vol. 24 (1), pp. 400. Date of Electronic Publication: 2024 Nov 11.
DOI: 10.1186/s12876-024-03491-6
Abstrakt: Background: Celiac disease (CD) affects the small intestine and can hinder nutrient absorption. It is found worldwide and common in certain groups of people including individuals with Type 1 Diabetes Mellitus (T1DM). However, the prevalence of CD in the West African region is not documented. This study aimed to investigate the prevalence and pattern of CD autoimmunity in Nigerian children and adolescents diagnosed with T1DM.
Methods: This was a cross-sectional descriptive study of children and adolescents with T1DM at the Paediatric Endocrinology Clinic of seven selected tertiary health facilities in Nigeria. Information was collected on socio-demographics, clinical characteristics and anthropometrics. The subjects were screened for markers of CD autoimmunity using anti-tissue transglutaminase antibody (tTG) and anti-endomysial antibody (EMA). Endoscopy and duodenal biopsy were recommended for participants with elevated CD-specific antibodies.
Results: The study recruited a total of 104 children and adolescents with TIDM, out of which six participants (5.8%) had CD autoimmunity. All six participants were females, aged between 3 and 12 years, with a mean age of 9.2 ± 3.7 years. Participants with CD autoimmunity were more likely to have DM diagnosed before the age of 10 years compared to those without CD autoimmunity (83.3% vs. 37.7%, p = 0.149). Except for two participants, all individuals with CD autoimmunity experienced gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and bloating.
Conclusion: This study highlights the occurrence of CD autoimmunity in Nigerian children and adolescents with TIDM. Healthcare providers should consider screening for celiac disease in children and adolescents with T1DM, particularly in females and when gastrointestinal symptoms are present. Additionally, the findings from this study suggest that there is a high probability of a significant burden of CD, even within the general population in Nigeria. Therefore, it's important to maintain a high level of suspicion and to actively screen at-risk groups in clinical settings to ensure early diagnosis of CD.
Competing Interests: Declarations Ethics approval and consent to participate Ethical approval was obtained from the ethics committees of all the involved hospitals – Health Research and Ethics Committee of LASUTH (LREC/06/10/1121); Health Research and Ethics Committee of LUTH (ADM/DCST/HREC/2682); Ethics and Research Committee of OAUTHC (ERC/2019/07/05); Health Research Ethics Committee of OOUTH (OOUTH/HREC/377/2020AP); Research Ethics Committee of AKUTH (AKTH/MAC/SUB/12A/P-3/VI/2108); Research and Ethics Committee of ATBUTH (ATBUTH/ADM/42/VOL.1) and Research Ethics Committee of UI/UCH (UI/EC/24/0362). Written informed consent was obtained from all parents or guardians and assent from all subjects. Consent for publication Not applicable. Competing interests The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje