Harnessing natural compounds to modulate miRNAs in breast cancer therapy.

Autor: Aly SH; Department of Pharmacognosy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt., Abulsoud AI; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt.; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., Moustafa YM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt., Abdel Mageed SS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt., Abdelmaksoud NM; Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt., El-Dakroury WA; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt., Mohammed OA; Department of Pharmacology, College of Medicine, University of Bisha, Bisha, 61922, Saudi Arabia., Abdel-Reheim MA; Department of Pharmacology, College of Pharmacy, Shaqra University, Shaqra, 11961, Saudi Arabia. m.ahmed@su.edu.sa., Zaki MB; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat, Menoufia, 32897, Egypt., Rizk NI; Department of Biochemistry, Faculty of Pharmacy and Drug Technology, Egyptian Chinese University, Cairo, 11786, Egypt., Elshafei A; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt., Elimam H; Department of Biochemistry, Faculty of Pharmacy, University of Sadat City, Sadat, Menoufia, 32897, Egypt., Ashraf A; Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt., Doghish AS; Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt. ahmed_doghish@azhar.edu.eg.; Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, 11231, Egypt. ahmed_doghish@azhar.edu.eg.
Jazyk: angličtina
Zdroj: Functional & integrative genomics [Funct Integr Genomics] 2024 Nov 12; Vol. 24 (6), pp. 211. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1007/s10142-024-01489-7
Abstrakt: Breast cancer's complexity and heterogeneity continue to present significant challenges in its treatment and management. Emerging research has underscored the pivotal role of microRNAs (miRNAs) in breast cancer pathogenesis, acting as crucial regulators of gene expression. This review delivers an in-depth analysis of miRNAs, highlighting their dual functions as both oncogenes and tumor suppressors, and detailing their impact on key biological processes, including cell proliferation, apoptosis, and metastasis. The mechanisms underlying miRNA action, particularly their interactions with target mRNAs and the factors influencing these dynamics, are thoroughly explored. Additionally, the review discusses the therapeutic prospects of miRNAs, with a focus on innovative delivery systems like nanoparticles that improve the stability and effectiveness of miRNA-based therapies. It also addresses the anticancer effects of natural compounds, such as genistein, hesperidin, quercetin, curcumin, resveratrol, epigallocatechin-3-gallate (EGCG), and glyceollins, which modulate miRNA expression and contribute to tumor growth inhibition. These advances seek to address the limitations of conventional therapies, paving the way for targeted interventions in breast cancer. By integrating current insights on miRNA biology, therapeutic strategies, and the potential of natural products to regulate miRNA expression, this review aims to shed light on miRNA- and natural product-based approaches as promising avenues for enhancing breast cancer treatment outcomes.
Competing Interests: Declarations Ethics approval and consent to participate Not Applicable. Human and animal ethics Not applicable. Consent for publication Not applicable. Competing interests The authors declare no competing interests.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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