Metabolomic signatures associated with fetal growth restriction and small for gestational age: a systematic review.

Autor: Conde-Agudelo A; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. condeagu@hotmail.com., Villar J; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. jose.villar@wrh.ox.ac.uk.; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK. jose.villar@wrh.ox.ac.uk., Risso M; Hospital Universitario General de Villalba, Madrid, Spain., Papageorghiou AT; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK., Roberts LD; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Kennedy SH; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.; Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Nov 11; Vol. 15 (1), pp. 9752. Date of Electronic Publication: 2024 Nov 11.
DOI: 10.1038/s41467-024-53597-4
Abstrakt: The pathways involved in the pathophysiology of fetal growth restriction (FGR) and small for gestational age (SGA) are incompletely understood. We conduct a systematic review to identify metabolomic signatures in maternal and newborn tissues and body fluids samples associated with FGR/SGA. Here, we report that 825 non-duplicated metabolites were significantly altered across the 48 included studies using 10 different human biological samples, of which only 56 (17 amino acids, 12 acylcarnitines, 11 glycerophosphocholines, six fatty acids, two hydroxy acids, and eight other metabolites) were significantly and consistently up- or down-regulated in more than one study. Three amino acid metabolism-related pathways and one related with lipid metabolism are significantly associated with FGR and/or SGA: biosynthesis of unsaturated fatty acids in umbilical cord blood, and phenylalanine, tyrosine and tryptophan biosynthesis, valine, leucine and isoleucine biosynthesis, and phenylalanine metabolism in newborn dried blood spot. Significantly enriched metabolic pathways were not identified in the remaining biological samples. Whether these metabolites are in the causal pathways or are biomarkers of fetal nutritional deficiency needs to be explored in large, well-phenotyped cohorts.
Competing Interests: Competing interests A.T.P. is supported by the Oxford Partnership Comprehensive Biomedical Research Centre with funding from the NIHR Biomedical Research Centre (BRC) funding scheme. The views expressed herein are those of the authors and not necessarily those of the NHS, the NIHR, the Department of Health or any of the other funders. All other authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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