Association between apolipoprotein E gene polymorphism and early MR findings in individuals with acute intracerebral hemorrhage: A retrospective cohort analysis.

Autor: Yang Z; Department of Radiology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404000, China; School of Medicine, Chongqing University, Chongqing, 404010, China., Xiong Q; Department of Radiology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404000, China; School of Medicine, Chongqing University, Chongqing, 404010, China., He R; Department of Ultrasound Medicine, Chongqing Wanzhou District Maternal and Child Health Care Hospital, Wanzhou, Chongqing, 404000, China., Wu C; School of Medicine, Chongqing University, Chongqing, 404010, China; Department of Neurology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404010, China; Chongqing Municipality Clinical Research Center for Geriatric Diseases, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404000, China., Huang Y; School of Medicine, Chongqing University, Chongqing, 404010, China; Department of Neurology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404010, China., Li Q; School of Medicine, Chongqing University, Chongqing, 404010, China; Department of Neurology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404010, China., Liu X; Department of Radiology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing, 404000, China; School of Medicine, Chongqing University, Chongqing, 404010, China. Electronic address: paulliuxh@163.com.
Jazyk: angličtina
Zdroj: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association [J Stroke Cerebrovasc Dis] 2024 Nov 10; Vol. 34 (1), pp. 108128. Date of Electronic Publication: 2024 Nov 10.
DOI: 10.1016/j.jstrokecerebrovasdis.2024.108128
Abstrakt: Objective: The Apolipoprotein E (APOE) gene plays a significant role in the development and prognosis of intracerebral hemorrhage (ICH). Imaging features identified within 48 h of ICH onset, particularly on magnetic resonance imaging (MRI), are indicative of cerebral small vessel diseases (CSVD). Our study aimed to assess these imaging characteristics and investigate their association with the APOE gene among ICH patients.
Methods: Clinical and imaging data from patients meeting specific inclusion and exclusion criteria from October 2021 to March 2022 were collected. MR signs or scores were evaluated following international accreditation standards and then analyzed in connection with the APOE allele genes.
Results: In a cohort of 220 patients, ε2 was identified as an independent risk factor for the "multiple subcortical spots" sign (OR = 13.29, 95% CI 1.88-22.59). Furthermore, ε4 emerged as an independent risk factor for the presence of perivascular space (PVS) in the centrum semiovale (OR = 2.46, 95% CI 1.03-5.89) and basal ganglia (OR = 2.64, 95% CI 1.10-6.35), as well as for cerebral microbleeds (CMB) across all locations (OR = 2.38, 95% CI 1.15-6.97), lobar CMB (OR = 2.92, 95% CI 1.11-7.65), and deep CMB (OR = 2.29, 95% CI 1.12-8.67).
Conclusion: The association between APOE ɛ2 and ɛ4 alleles and the presence of "subcortical multiple spots," "PVS," and "CMB" indirectly implies the potential role of APOE gene-related pathological changes in the progression of ICH and small vessel pathology.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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