Association of hypertensive disorder of pregnancy with necrotizing enterocolitis in very preterm infants: A retrospective cohort study.

Autor: Chen W; Department of Neonatology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China., Yang J; NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, Shanghai, China., Jiang S; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Lei X; Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China., Zhou L; Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China., Zhou J; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Hu L; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Gu X; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Yun C; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Du L; Neonatal Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.; National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, China., Zhou W; Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China., Lee S; Maternal-Infant Care Research Centre and Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada., Yang C; Department of Neonatology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China., Hu Y; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Nov 11; Vol. 19 (11), pp. e0313035. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0313035
Abstrakt: Hypertensive disorders of pregnancy (HDP) may affect fetal development and result in preterm delivery. Necrotizing enterocolitis (NEC) is a severe gastrointestinal emergency in very preterm infants (VPIs, gestational age less than 32 weeks). The relationship between maternal HDP and NEC is controversial. Objective To investigate the association between maternal HDP and NEC in VPIs.This was a multicenter retrospective cohort study based on the data from the Chinese Neonatal Network (CHNN) which were collected between January 1, 2019 and December 31, 2021. Preterm infants born between 24+0 and 31+6 weeks of gestation were divided into HDP and no-HDP groups according to the 2015 Chinese guidelines for HDP. The primary outcome was the incidence of Bell's stage II or higher NEC. Secondary outcomes included mortality and spontaneous intestinal perforation (SIP). Of 27,660 women were included in the study analysis, 5405 (19.5%) were HDP and 22256 (80.5%) were no-HDP. NEC occurred in 5.2% (283/5,404) among HDP mothers and 5.3% (1,191/22,256) among no-HDP mothers. No significant association was observed between HDP and Bell's stage II or higher NEC (aOR 0.87, 95% CI [0.72, 1.05]). However, even after adjustment, maternal HDP appeared to be protective for NEC requiring surgical intervention (aOR 0.60, 95% CI [0.43, 0.83]). There was no significant correlation between maternal HDP and neonatal mortality and SIP. Maternal HDP was not significantly associated with the incidence of Bell's stage II or higher NEC. However, it was associated with the lower rate of NEC requiring surgical intervention.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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