| Autor: |
Safaie N; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Idari G; Department of Clinical Biochemistry, Mashhad University of Medical Sciences, Mashhad, Iran., Ghasemi D; Stem Cell research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Hajiabbasi M; Islamic Azad University of Tonekabon, Tonekabon, Iran., Alivirdiloo V; Ramsar Campus, Mazandaran University of Medical Sciences, Ramasr, Iran., Masoumi S; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Vanderbilt University of Medical center, Nashville, TN, USA., Zavvar M; Department of Medical Laboratory Science, School of Allied Medicine Sciences (SAMS), Tehran University of Medical Sciences (TUMS), Tehran, Iran., Majidi Z; Department of Medical Laboratory Science, School of Allied Medicine Sciences (SAMS), Tehran University of Medical Sciences (TUMS), Tehran, Iran., Faridvand Y; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
| Abstrakt: |
The introduction of Tyrosine Kinase Inhibitors (TKIs) has revolutionised cancer treatment, yet concerns regarding cardiovascular toxicity have surfaced. This piece delves into the interplay between AMP-activated protein kinase (AMPK) signalling and TKI-induced cardiovascular toxicity. The study unravels the intricate relationship between AMPK activation and TKI-induced cardiovascular toxicity, aiming to ascertain whether AMPK can play a strategic role in mitigating adverse effects. Beyond unravelling mechanistic insights, the research sets the stage for future therapeutic approaches, envisioning AMPK activation as a pivotal connection for balancing effective cancer treatment with cardiovascular well-being. As research advances, the potential of AMPK activation not only addresses challenges in TKI-induced cardiovascular toxicity but also shapes the future landscape of personalised anticancer therapies. The article explores the mechanisms of TKI-induced toxicity, AMPK's impact on cardiovascular health, and the potential therapeutic implications of AMPK activation in alleviating TKI-associated toxicities. |
