Bidirectional association of sleep disorders with chronic kidney disease: a systematic review and meta-analysis.

Autor:	Koh JH; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Lim CYJ; Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand., Yam KJM; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Yeo BSY; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Ng ACW; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore, Singapore., Loh SRH; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore, Singapore.; Signature Research Programme in Neuroscience & Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore., Hsu PP; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Signature Research Programme in Neuroscience & Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore.; Department of Otolaryngology, Sengkang General Hospital, Singapore, Singapore., Gooley J; Signature Research Programme in Neuroscience & Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore., Tan CS; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Signature Research Programme in Neuroscience & Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore.; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore., Toh ST; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Department of Otorhinolaryngology-Head & Neck Surgery, Singapore General Hospital, Singapore, Singapore.; Signature Research Programme in Neuroscience & Behavioural Disorders, Duke-NUS Medical School, Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	Clinical kidney journal [Clin Kidney J] 2024 Oct 18; Vol. 17 (11), pp. sfae279. Date of Electronic Publication: 2024 Oct 18 (Print Publication: 2024).
DOI:	10.1093/ckj/sfae279
Abstrakt:	Background: Published studies have suggested a link between chronic kidney disease (CKD) and sleep disorders, although the exact nature of this association has not been uniformly described. Clarifying this relationship may facilitate evidence-based interventions that address the interplay between these disease entities. Such interventions could prevent obstructive sleep apnea (OSA) from worsening CKD and improve the quality of life for CKD patients by reducing the risk of developing OSA. Therefore, the objective of this meta-analysis is to assess the bidirectional association between sleep disorders and CKD. Methods: Following a PROSPERO-registered protocol, three blinded reviewers conducted a systematic review of the Medline/PubMed, Embase, Cochrane Library and Cumulative Index of Nursing and Allied Health (CINAHL) databases for observational studies pertaining to the relationship between sleep disorders and CKD. A meta-analysis was conducted in risk ratios (RRs). Results: From 63 studies (26 777 524 patients), OSA [RR 1.68; 95% confidence interval (CI) 1.45 to 1.93], albuminuria (RR 1.54; 95% CI 1.18 to 1.99), restless leg syndrome (RLS) (RR 1.88; 95% CI 1.48 to 2.38) and insomnia (RR 1.24; 95% CI 1.01 to 1.54) were significantly associated with CKD. There was a significant association between OSA (RR 1.77; 95% CI 1.56 to 2.01) with incident CKD. There was a significant association of OSA (RR 1.74; 95% CI 1.55 to 1.96), RLS (RR 1.73; 95% CI 1.32 to 2.25) and insomnia (RR 1.14; 95% CI 1.03 to 1.27) in patients with CKD compared with healthy controls. CKD was also significantly associated with incident OSA (RR 1.60; 95% CI 1.35 to 1.89). Conclusion: The bidirectional associations of obstructive sleep apnea with CKD remained consistent across different stages of CKD, modes of diagnosis of sleep disorder and geographical region. A bidirectional association was observed between CKD and obstructive sleep apnea, RLS and insomnia. The treatment of sleep disorders may reduce the risk of CKD, and vice versa. Competing Interests: The authors declare no conflicts of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of the ERA.)
Databáze:	MEDLINE
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