Invasive fungal infection in patients with hematologic malignancies: epidemiology and prognostic factors.

Autor:	Jebari M; Laboratory of Parasitology-Mycology, Military Hospital of Tunis, Tunis, Tunisia.; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia., Mtibaa L; Laboratory of Parasitology-Mycology, Military Hospital of Tunis, Tunis, Tunisia.; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia., Ghedira H; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.; Department of Hematology, Military Hospital of Tunis, Tunis, Tunisia., Baccouchi N; Laboratory of Parasitology-Mycology, Military Hospital of Tunis, Tunis, Tunisia., Zriba S; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.; Department of Hematology, Military Hospital of Tunis, Tunis, Tunisia., Msadek F; Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.; Department of Hematology, Military Hospital of Tunis, Tunis, Tunisia., Jemli B; Laboratory of Parasitology-Mycology, Military Hospital of Tunis, Tunis, Tunisia.; Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Jazyk:	angličtina
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2024 Jul 24; Vol. 48, pp. 130. Date of Electronic Publication: 2024 Jul 24 (Print Publication: 2024).
DOI:	10.11604/pamj.2024.48.130.40509
Abstrakt:	Invasive fungal infections (IFI) are emerging opportunistic diseases that occur mainly in immunocompromised patients. Our study aimed to analyze the epidemiology of IFIs in patients with hematological malignancies, and the prognostic factors. Our retrospective study included patients hospitalized in the hematology department between January 1 st , 2010, and August 31 st , 2020, and in whom the diagnosis of IFI was made according to the EORTC criteria 2008. We found 29 IFIs among 6989 admissions (0.4%). IFIs were proven in 16 cases and probable in 13 cases. The median age was 35 years. The sex ratio was 0.9. The predominant IFI was invasive pulmonary aspergillosis (n=14) followed by fungemia (n=13). Candida albicans was the most isolated species in blood cultures (5/9). The mortality rate was 48%. In multivariate analysis, disease status, time to start antifungal treatment, and lactate levels are significant factors of excess mortality. IFIs are responsible for significant morbidity and mortality. The challenge lies in the precocity of starting the treatment as well as the vigilance given to the factors of poor prognosis. Competing Interests: The authors declare no competing interests. (Copyright: Maroua Jebari et al.)
Databáze:	MEDLINE
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