Recent Progress in Synthetic and Natural Catechol- O -methyltransferase Inhibitors for Neurological Disorders.

Autor:	Bindra S; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science campus, Kochi 682041, India., Datta A; Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi 110021, India., Yasin HKA; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman 346, United Arab Emirates.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, P. O. Box 346, Ajman 346, United Arab Emirates., Thomas RR; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science campus, Kochi 682041, India., Verma S; Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi 110021, India., Patel A; Department of Biochemistry, Sri Venkateswara College, University of Delhi, New Delhi 110021, India., Parambi DGT; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, Saudi Arabia., Mali SN; School of Pharmacy, D.Y. Patil University (Deemed to be University), Sector 7, Nerul, 400706 Navi Mumbai, India., Rangarajan TM; Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi 110021, India., Mathew B; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science campus, Kochi 682041, India.
Jazyk:	angličtina
Zdroj:	ACS omega [ACS Omega] 2024 Oct 23; Vol. 9 (44), pp. 44005-44018. Date of Electronic Publication: 2024 Oct 23 (Print Publication: 2024).
DOI:	10.1021/acsomega.4c06190
Abstrakt:	Catechol- O -methyltransferase (COMT) inhibitors have played a crucial role in the development of potent and selective drugs for the treatment of Parkinson's disease, depression, and anxiety disorders. This review provides a comprehensive analysis of the structure-activity relationship (SAR) of COMT inhibitors, highlighting key structural features and pharmacophoric elements that govern their potency, selectivity, and pharmacokinetic properties. This review also discusses the application of SAR principles in the design and optimization of COMT inhibitors. Our analysis reveals the emergence of novel chemical scaffolds and the potential for COMT inhibitors to address unmet medical needs in neurology and psychiatry. This Perspective serves as a valuable resource for clinicians and researchers, providing insights into the rational design of COMT inhibitors and the development of next-generation therapeutics. Competing Interests: The authors declare no competing financial interest. (© 2024 The Authors. Published by American Chemical Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu