Effectiveness and safety of chlorhexidine gluconate double-cleansing for surgical site infection prevention in neonatal intensive care unit surgical patients.

Autor:	Kwon JA; Department of Surgery, Ulsan University Hospital, Ulsan, Korea., Cho MJ; Department of Surgery, Ulsan University Hospital, Ulsan, Korea.; Department of Surgery, University of Ulsan College of Medicine, Ulsan, Korea.
Jazyk:	angličtina
Zdroj:	Annals of surgical treatment and research [Ann Surg Treat Res] 2024 Nov; Vol. 107 (5), pp. 291-299. Date of Electronic Publication: 2024 Oct 29.
DOI:	10.4174/astr.2024.107.5.291
Abstrakt:	Purpose: This study assessed the efficacy and safety of preoperative chlorhexidine gluconate (CHG) double-cleansing in reducing the incidence of surgical site infections (SSI) in surgical patients in neonatal intensive care units. Methods: A retrospective chart review involved 56 patients who underwent 73 surgical procedures in the neonatal intensive care unit (NICU) from 2013 to 2022. CHG double-cleansing involves the following 2 processes. Firstly, preoperative cleansing with 0.5% CHG for elective surgeries the night before or at least 1 hour before emergency surgery. The anterior trunk cleansing spanned from the neck to the pubis, including both axillary lines. Secondly, the surgical site underwent skin preparation using 2% CHG with 72% isopropyl alcohol before an incision. A control group (2013-2018) that used iodine and a CHG group (2019-2022) employing CHG double-cleansing were compared. The occurrence of SSIs within 30 days after the surgical procedure was assessed. Results: The overall SSI rate was 16.4% (n = 12) in the total procedures. The SSI rate was significantly higher (22.6%) in the control group; no SSI occurred in the CHG group (P = 0.029). No significant differences were observed in the other parameters. No adverse effects were observed in the CHG group. Conclusion: CHG double-cleansing, a modified approach for surgical patients in the NICU, effectively reduced the incidence of SSI compared to traditional iodine-based skin preparations. This study supports the safe use of CHG in neonates, including premature infants, without significant complications. Competing Interests: Conflict of Interest: No potential conflict of interest relevant to this article was reported. (Copyright © 2024, the Korean Surgical Society.)
Databáze:	MEDLINE
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