| Autor: |
Huang R; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China., Hu C; Department of Interventional Radiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Zhejiang Key Laboratory of Imaging and Interventional Medicine, Hangzhou, Zhejiang 310022, China.; Zhejiang Provincial Research Center for Innovative Technology and Equipment in Interventional Oncology, Hangzhou, Zhejiang 310022, China., Xu S; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China., Chen H; Department of Orthopaedic Surgery, Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China., Pan J; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China., Xia J; Department of Emergency, Qingdao West Coast New Area Central Hospital, Qingdao 266000, China., Xie D; Department of Emergency, Qingdao West Coast New Area Central Hospital, Qingdao 266000, China., Jin Y; Department of Emergency, Qingdao West Coast New Area Central Hospital, Qingdao 266000, China., Wang Z; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China., Zhao C; Department of Orthopaedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. |
| Abstrakt: |
The critical-sized bone defect resulting from trauma, tumor resection, and congenital deformity fails to undergo spontaneous healing due to its substantial size, while the ensuing inflammatory process and hypoxic environment further impede the regenerative process. Therefore, it has consistently presented a significant clinical challenge. In the present study, we incorporate a glycyrrhizic acid (GA)-functionalized hydrogel onto the surface of a Hydroxyapatite (Hap)-modified Polycaprolactone (PCL) scaffold to fabricate a composite scaffold. The composed scaffold showed favorable anti-inflammatory and antioxidative capabilities by modulating macrophage polarization and scavenging reactive oxygen species (ROS); the modification of Hap enhanced its osteogenic ability. An in vivo rat skull defect model confirmed that the composed scaffold efficiently promotes bone regeneration. In general, the composed scaffold with the ability of osteoimmune microenvironment regulation can effectively repair critical-sized bone defects. This strategy provides a promising method for the reconstruction of large segmental bone defects. |
