Clinical and genetic characteristics of simple central serous chorioretinopathy according to age.

Autor:	Shijo T; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Fukui A; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.; Department of Ophthalmology, Kyoto Chubu Medical Center, Nantan, Japan., Sakurada Y; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Terao N; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Yoneyama S; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Kusada N; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Sugiyama A; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Matsubara M; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Fukuda Y; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Kikushima W; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Kotoda Y; Department of Ophthalmology, University of Yamanashi, Chuo, Japan., Sotozono C; Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Kashiwagi K; Department of Ophthalmology, University of Yamanashi, Chuo, Japan.
Jazyk:	angličtina
Zdroj:	Ophthalmic genetics [Ophthalmic Genet] 2024 Nov 10, pp. 1-6. Date of Electronic Publication: 2024 Nov 10.
DOI:	10.1080/13816810.2024.2426559
Abstrakt:	Purpose: To investigate whether genetic and clinical characteristics differ depending on generations using 326 patients (male/female, 259/67; mean age, 55.4 ± 12.5 years) with simple CSC. Methods: All patients were diagnosed with simple CSC, defined as a retinal pigment epithelium alteration area equal to or smaller than 2-disc areas based on multimodal imaging at the initial presentation. We cross-sectionally evaluated clinical characteristics at the initial visit and genotyped CFH rs800292 and rs1329428 for all patients using TaqMan technology. Results: As generations decreased, the proportion of males, subfoveal choroidal thickness, and prevalence of fibrin significantly increased ( p  < 0.001, p  < 0.001, and p  = 0.012, respectively), and the best-corrected visual acuity improved ( p  < 0.001); in contrast, the prevalence of pachydrusen significantly decreased ( p  < 0.001). The younger presentation was significantly associated with male and risk variants (T allele) of CFH rs1329428 ( p  = 9.1 × 10 -7 and p  = 0.042, respectively), and patients were estimated to present 2 years younger per one T allele of CFH rs1329428 ( p  = 0.042, β = -1.95, stepwise regression analysis). Conclusion: Clinical and genetic characteristics differed significantly among patients with simple CSC, depending on their generation.
Databáze:	MEDLINE
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