Polydopamine Nanobowl-Armoured Perfluorocarbon Emulsions: Tracking Thermal- and Photothermal-Induced Phase Change through Neutron Scattering.

Autor: Vidallon MLP; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; School of Chemistry, Monash University, Clayton, VIC, 3800, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, 3086, Australia., Liu H; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia., Lu Z; Department of Chemical Engineering, University of Melbourne, Parkville, 3010, Australia., Acter S; Department of Radiation Oncology and Molecular Sciences, The Johns Hopkins School of Medicine, Johns Hopkins University, 733 N Broadway, Baltimore, MD, 21205, USA., Song Y; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia., Baldwin C; Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Rd, Lucas Heights, NSW, 2234, Australia., Teo BM; School of Chemistry, Monash University, Clayton, VIC, 3800, Australia., Bishop AI; School of Physics and Astronomy, Monash University, Clayton, VIC, 3800, Australia., Tabor RF; School of Chemistry, Monash University, Clayton, VIC, 3800, Australia., Peter K; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, 3086, Australia.; Atherothrombosis and Vascular Biology Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia., de Campo L; Australian Nuclear Science and Technology Organization (ANSTO), New Illawarra Rd, Lucas Heights, NSW, 2234, Australia., Wang X; Molecular Imaging and Theranostics Laboratory, Baker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.; Baker Department of Cardiometabolic Health, University of Melbourne, Parkville, VIC, 3010, Australia.; Baker Department of Cardiovascular Research, Translation and Implementation, La Trobe University, Bundoora, VIC, 3086, Australia.; School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Nov 10, pp. e2406019. Date of Electronic Publication: 2024 Nov 10.
DOI: 10.1002/smll.202406019
Abstrakt: Anisotropic polydopamine nanobowls (PDA NBs) show significant promise in biomedicine, distinguished by their unique optical properties and superior cellular uptake compared to spherical nanoparticles. This study presents a novel approach for creating multistimuli-activated PDA NB-armored emulsions, encapsulating perfluorohexane (NB-H) and perfluoropentane (NB-P) cores, with applications in controlled delivery and ultrasound imaging. Thermal and photothermal activation induced distinct responses in the emulsions, as evidenced by optical microscopy and thermogravimetric analysis. For the first time, neutron scattering techniques (SANS and USANS) under contrast matching conditions are applied to investigate these materials, revealing detailed droplet and microbubble structures and phase transition dynamics. These results show that NB-H droplets resist phase change under direct heating, whereas NB-P droplets respond more readily, exhibiting significant bubble formation. During photothermal activation with short near-infrared (NIR) exposure (15 min at 400 mW cm -2 ), SANS and USANS analyses reveal varying degrees of phase transition, proving this activation method to be more effective than direct heating. Importantly, NB-H and NB-P droplets have excellent ultrasound contrast enhancement and biocompatibility, indicating their potential for contrast-enhanced ultrasound imaging, theranostics, and photothermal applications. This comprehensive study advances the understanding of multifunctional colloidal materials in biomedicine, contributing essential knowledge to this rapidly evolving field.
(© 2024 The Author(s). Small published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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