Exploring the cognitive effects of hearing loss in adult rats: Implications for visuospatial attention, social behavior, and prefrontal neural activity.

Autor: Stenzel M; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Alam M; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Witte M; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Jelinek J; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Armbrecht N; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Armstrong A; Institute of AudioNeuroTechnology, Hannover Medical School, Stadtfelddamm 34, 30625 Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Stadtfelddamm 34, 30625 Hannover, Germany., Kral A; Cluster of Excellence Hearing4all, German Research Foundation, Hanover, Germany; Institute of AudioNeuroTechnology, Hannover Medical School, Stadtfelddamm 34, 30625 Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Stadtfelddamm 34, 30625 Hannover, Germany., Krauss JK; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany., Land R; Institute of AudioNeuroTechnology, Hannover Medical School, Stadtfelddamm 34, 30625 Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Stadtfelddamm 34, 30625 Hannover, Germany., Schwabe K; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany; Cluster of Excellence Hearing4all, German Research Foundation, Hanover, Germany., Johne M; Department of Neurosurgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hanover, Germany; Cluster of Excellence Hearing4all, German Research Foundation, Hanover, Germany. Electronic address: johne.marie@mh-hannover.de.
Jazyk: angličtina
Zdroj: Neuroscience [Neuroscience] 2025 Jan 09; Vol. 564, pp. 97-109. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1016/j.neuroscience.2024.11.010
Abstrakt: Age-related hearing loss in humans has been associated with cognitive decline, though the underlying mechanisms remain unknown. We investigated the long-term effects of hearing loss on attention, impulse control, social interaction, and neural activity within medial prefrontal cortex (mPFC) subregions. Hearing loss was induced in adult rats via intracochlear neomycin injection (n = 13), with non-operated rats as controls (n = 10). Rats were tested for motor activity (open field), coordination (Rotarod), and social interaction (including ultrasonic vocalization, USV) before surgery and at weeks 1, 2, 4, 8, 16, and 24 post-surgery. From week 8 on, rats were trained in the five-choice serial reaction time task (5-CSRTT) to assess visuospatial attention and impulse control. Finally, oscillatory neuronal activity in mPFC subregions was recorded with multielectrode arrays during anesthesia, followed by immunohistological staining for NeuN + and Parvalbumin + cells. Deafened rats were more active than controls, whereas social interaction and USV were temporarily reduced. They also had difficulties to learn the concept of the 5-CSRTT paradigm and made more incorrect responses. Electrophysiology showed decreased power in theta, alpha, and beta frequency, and enhanced high gamma band in the mPFC in deafened rats, which was most pronounced in the cingulate subregion (Cg1). The number of NeuN + and Parvalbumin + cells, however, did not differ between groups. The behavioral deficits together with the altered neuronal activity found in the Cg1 subregion of the mPFC in adult deafened rats may be used as an endophenotype to elucidate the mechanisms behind the cognitive decline seen in older patients with hearing loss.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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