Direct photoelectrochemical detection of ethanol in complex biological sample.

Autor: Yan W; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China., Huang Q; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China., Zhou L; Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou, 310058, China., Lin X; College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. Electronic address: xingyu@zju.edu.cn.
Jazyk: angličtina
Zdroj: Biosensors & bioelectronics [Biosens Bioelectron] 2025 Jan 15; Vol. 268, pp. 116915. Date of Electronic Publication: 2024 Nov 06.
DOI: 10.1016/j.bios.2024.116915
Abstrakt: The development of advanced photoelectrochemical (PEC) technology for the direct detection of ethanol in complex biological sample, has become a hot topic. However, the photo-active nanomaterials, which could generate the photo-induced carriers under illumination, are susceptible to biofouling and interference in complex bio-matrices. In this work, the silica nanochannel-protected TiO 2 nanomaterials was reported for the first time that enables the direct sensing of ethanol in real fruits and untreated whole blood. The modification of SNC enhanced the sensitivity of ethanol detection by promoting light absorption, electron-hole separation, and surface reaction rate of photo-active materials. Meanwhile, the biofouling macromolecules and interference signals can be effectively excluded due to the hydrophilic properties, size, and electrostatic exclusion of nanochannels. As a result, without any complex sample pretreatments, the proposed PEC sensor can be directly immersed in complex biological samples for ethanol detection, exhibiting a broad linear range (1.775 μM-20 mM) and a low detection limit (1.2 μM), as well as excellent reproducibility and stability. This work paves a new path for PEC sensors in real biomedical applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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