Are symptoms in pathologic scars related to nerve function or density? A scoping review.

Autor: De Henau M; Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands. Electronic address: Melissa.de.henau@mumc.nl., Schins S; Scannexus, Oxfordlaan 55, 6229 EV Maastricht, the Netherlands., Colla C; Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands., van den Kerckhove E; Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; Department of Rehabilitation Sciences, FaBeR, KU Leuven, Gymnasium, 3001 Leuven, Belgium; Department of Physical Medicine and Rehabilitation and Burns Center, Universitaire Ziekenhuizen Leuven, Herestraat 49, 3000 Leuven, Belgium., van der Hulst R; Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands., Tuinder S; Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands.
Jazyk: angličtina
Zdroj: Burns : journal of the International Society for Burn Injuries [Burns] 2024 Oct 10; Vol. 51 (1), pp. 107280. Date of Electronic Publication: 2024 Oct 10.
DOI: 10.1016/j.burns.2024.10.001
Abstrakt: Background: Hypertrophic scars and keloids are forms of pathologic scarring that can give rise to pain and pruritus. The link between nerve function and nerve density and the symptoms in pathologic scars (PS) remains unclear.
Objective: We aim to assess current knowledge on nerve function and nerve density in PS, and to explore a possible association between alterations in sensibility/nerve density and pathologic scar symptoms.
Methods: A scoping review was conducted. After performing a systematic search using PubMed, Embase and Web-of-Science, relevant papers were selected and analyzed by 2 reviewers. Data was charted in tables in combination with a narrative summary of main findings.
Results: Nineteen studies were included. Overall, functional sensibility in PS seems disturbed, with a higher frequency of allodynia and altered thermosensory thresholds, suggesting involvement of small fiber neuropathy. Nerve fiber density varied with the investigated skin layer and the used staining techniques, which implied limitations to compare findings from different studies. However, evidence suggests involvement of neuropeptides in the pathologic scar formation and symptomatology.
Conclusions: Wide heterogeneity between studies exists. Therefore, no firm conclusions can be formulated. However, evidence suggests involvement of the cutaneous nervous system by neurogenic inflammation in the pathophysiology of pathologic scars and their symptoms.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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