Endogenous ZAP is associated with altered Zika virus infection phenotype.

Autor: Le NPK; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, OH, Columbus, USA., Singh PP; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, OH, Columbus, USA.; School of Public Health, University of Saskatchewan, Saskatoon, Canada., Sabir AJ; Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, USA, IL., Trus I; International Institute of Molecular and Cell Biology, Dioscuri Centre for RNA-Protein Interactions in Human Health and Disease, Warsaw, Poland., Karniychuk U; Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, OH, Columbus, USA. karniychuk.1@osu.edu.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2024 Nov 09; Vol. 21 (1), pp. 285. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1186/s12985-024-02557-x
Abstrakt: The zinc finger antiviral protein 1 (ZAP) has broad antiviral activity. ZAP is an interferon (IFN)-stimulated gene, which itself may enhance type I IFN antiviral response. In a previous study, Zika virus was identified as ZAP-resistant and not sensitive to ZAP antiviral activity. Here, we found that ZAP was associated with the inhibition of Zika virus in Vero cells, in the absence of a robust type I IFN system because Vero cells are deficient for IFN-alpha and -beta. Also, quantitative RNA-seq data indicated that endogenous ZAP is associated with altered global gene expression both in the steady state and during Zika virus infection. Further studies are warranted to elucidate this IFN-alpha and -beta independent anti-Zika virus activity and involvement of ZAP.
(© 2024. The Author(s).)
Databáze: MEDLINE
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