Anhedonia is associated with a specific depression profile and poor antidepressant response.

Autor:	Luca A; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy., Luca M; Centre for Addiction, Adrano-Bronte, Italy., Kasper S; Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria.; Department of Molecular Neuroscience, Center for Brain Research, Medical University Vienna, Vienna, Austria., Pecorino B; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy., Zohar J; 5Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Souery D; Psy Pluriel - Epsylon Caring for Mental Health Brussels and Laboratoire de Psychologie Médicale Université libre de Bruxelles, Bruxelles, Belgium., Montgomery S; Imperial College School of Medicine, London, United Kingdom., Ferentinos P; Department of Psychiatry, Athens University Medical School, Athens, Greece., Rujescu D; Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna, Austria., Messina A; Psychiatry Unit, Department of Mental Health, ASP Enna, Enna, Italy., Zanardi R; Department of Clinical Neurosciences, Vita-Salute San Raffaele University, Milan, Italy.; Mood Disorder Unit, IRCCS San Raffaele Hospital, Milan, Italy., Ferri R; Oasi Research Institute-IRCCS, Troina, Italy., Tripodi M; Oasi Research Institute-IRCCS, Troina, Italy., Baune BT; Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany.; Department of Psychiatry, Melbourne Medical School, University of Melbourne, Parkville, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia., Fanelli G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Department of Human Genetics, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands., Fabbri C; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Mendlewicz J; Université Libre de Bruxelles, Brussels, Belgium., Serretti A; Department of Medicine and Surgery, Kore University of Enna, Enna, Italy.; Oasi Research Institute-IRCCS, Troina, Italy.
Jazyk:	angličtina
Zdroj:	The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2024 Dec 01; Vol. 27 (12).
DOI:	10.1093/ijnp/pyae055
Abstrakt:	Background: Anhedonic features within major depressive disorder (MDD) have been associated with worse course and outcome and may predict nonresponse to treatment. However, a detailed clinical profile of anhedonia in MDD is still lacking. Materials and Methods: One thousand two hundred ninety-four patients with MDD were selected from the cross-sectional European multicenter Group for the Study of Resistant Depression study. Anhedonia was assessed through the Montgomery-Åsberg Depression Rating Scale anhedonia item "inability to feel." Clinical and demographic features were then analyzed. Results: The presence of anhedonia related to a distinct demographical (living alone) and clinical profile (thyroid diseases, diabetes, suicide risk, high number of previous depressive episodes, more severe MDD, and more frequent inpatient status). Furthermore, anhedonia was associated with nonresponse to treatment and treatment resistance, even after adjusting for confounding variables. Conclusions: Our findings support the role of anhedonia as a modulating feature of MDD, being associated with a more severe depression profile. Moreover, anhedonic features are independent predictors of poor treatment response. (© The Author(s) 2024. Published by Oxford University Press on behalf of CINP.)
Databáze:	MEDLINE
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