Biomimetics through bioconjugation of 16-methylheptadecanoic acid to damaged hair for hair barrier recovery.

Autor: Song SH; LG Household and Health Care, Gangseo-gu, Seoul, 07795, Republic of Korea. sanghun@uw.edu., Park HS; LG Household and Health Care, Gangseo-gu, Seoul, 07795, Republic of Korea., Lim BT; LG Household and Health Care, Gangseo-gu, Seoul, 07795, Republic of Korea., Son SK; LG Household and Health Care, Gangseo-gu, Seoul, 07795, Republic of Korea.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 09; Vol. 14 (1), pp. 27387. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1038/s41598-024-78770-z
Abstrakt: The primary component of the lipid barrier on human hair, which is essential for defense against aging and environmental stresses, is 18-methyleicosanoic acid (18-MEA), which provides hydrophobic properties and protective benefits. Since 18-MEA cannot be regenerated once damaged, developing technology that can permanently bind alternative materials to hair is critical. Once 18-MEA was removed from hair via X-ray photoelectron spectroscopy (XPS), pentaerythritol tetraisoosterate (PTIS) was hydrolyzed and observed via gas chromatography/mass spectrometry (GC/MS) to confirm that it mimicked 18-MEA, and 16-methylheptadecanoic acid (16-MHA) was obtained at pH 4 or lower. 16-MHA was bioconjugated to damaged hair from which 18-MEA was removed via a carbodiimide reaction using polycarbodiimide. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) confirmed that 16-MHA remained on the surface of the bioconjugated hair even after washing. Observation of the endothermic reaction of moisture in hair via a differential scanning calorimetry (DSC) and evaluation of the moisture content confirmed that the physical properties of hair enriched with 16-MHA were similar to those of virgin hair. This biomimetic approach has been shown to restore both external structural integrity and internal moisture homeostasis.
(© 2024. The Author(s).)
Databáze: MEDLINE
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