Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon.

Autor: Barros MC; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., de Souza JES; Graduate Program Bioinformatics, Federal University of Rio Grande do Norte (UFRN), Natal, 59078-970, RN, Brazil.; Multidisciplinary Bioinformatics Center (BiOMe), Federal University of Rio Grande do Norte (UFRN), Natal, 59078-970, RN, Brazil., Gomes DHF; Graduate Program Bioinformatics, Federal University of Rio Grande do Norte (UFRN), Natal, 59078-970, RN, Brazil., Pinho CT; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., Silva CS; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., Braga-da-Silva C; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., Cavalcante GC; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., Magalhães L; Vale Technological Institute (ITV), Belém, 66055-090, PA, Brazil., Azevedo-Pinheiro J; Laboratory of Human and Medical Genetics (LGHM) / Graduate Program Genetics and Molecular Biology (PPGBM), Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil., Quaresma JAS; Laboratory of Infectious Disease, School of Medicine, Federal University of Pará (UFPA), Belém, 66075-110, PA, Brazil.; Department of Infectious Disease, School of Medicine, State University of Pará (UEPA), Belém, 66087-670, PA, Brazil., Falcão LFM; Department of Infectious Disease, School of Medicine, State University of Pará (UEPA), Belém, 66087-670, PA, Brazil., Costa PF; Dermatology and Immunology Laboratory, Federal University of Pará (UFPA), Marituba, 67105-290, PA, Brazil., Salgado CG; Dermatology and Immunology Laboratory, Federal University of Pará (UFPA), Marituba, 67105-290, PA, Brazil., Carneiro TX; Molecular Biology Laboratory, Ophir Loyola Hospital (HOL), Belém, 66063-240, PA, Brazil., Burbano RR; Molecular Biology Laboratory, Ophir Loyola Hospital (HOL), Belém, 66063-240, PA, Brazil., Dos Santos Vieira JR; Institute of Biological Sciences, Federal University of Pará (UFPA), Belém, 66075- 110, PA, Brazil., Santos S; Center of Oncology Research, Federal University of Pará (UFPA), Belém, 66073- 005, PA, Brazil., Soares-Souza GB; Vale Technological Institute (ITV), Belém, 66055-090, PA, Brazil. jwojwo@gmail.com., de Souza SJ; Graduate Program Bioinformatics, Federal University of Rio Grande do Norte (UFRN), Natal, 59078-970, RN, Brazil. sandro@i2bio.org.; Multidisciplinary Bioinformatics Center (BiOMe), Federal University of Rio Grande do Norte (UFRN), Natal, 59078-970, RN, Brazil. sandro@i2bio.org.; DNA-GTX Bioinformatics, Natal, RN, Brazil. sandro@i2bio.org., Ribeiro-Dos-Santos Â; Center of Oncology Research, Federal University of Pará (UFPA), Belém, 66073- 005, PA, Brazil. akelyufpa@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 09; Vol. 14 (1), pp. 27332. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1038/s41598-024-78170-3
Abstrakt: Despite all the efforts acquired in four years of the COVID-19 pandemic, the path to a full understanding of the biological mechanisms involved in this disease remains complex. This is partly due to a combination of factors, including the inherent characteristics of the infection, socio-environmental elements, and the variations observed within both the viral and the human genomes. Thus, this study aimed to investigate the correlation between genetic host factors and the severity of COVID-19. We conducted whole exome sequencing (WES) of 124 patients, categorized into severe and non-severe groups. From the whole exome sequencing (WES) association analysis, four variants (rs1770731 in CRYBG1, rs7221209 in DNAH17, rs3826295 in DGKE, and rs7913626 in CFAP46) were identified as potentially linked to a protective effect against the clinical severity of COVID-19, which may explain the less severe impact of COVID-19 on the Northern Region. Our findings underscore the importance of carrying out more genomic studies in populations living in the Amazon, one of the most diverse from the point of view of the presence of rare and specific alleles. To our knowledge, this is the first WES study of admixed individuals from the Brazilian Amazon to investigate genomic variants associated with the clinical severity of COVID-19.
(© 2024. The Author(s).)
Databáze: MEDLINE
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