A mesocorticolimbic insulin receptor gene co-expression network moderates the association between early life adversity and food approach eating behaviour style in childhood.

Autor: Jaramillo-Ospina AM; Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada., Dalle Molle R; Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Patel S; Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., Kelly S; Department of Psychology, Faculty of Arts, McGill University, Montreal, QC, Canada., Pokhvisneva I; Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada., de Weerth C; Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands., Silveira PP; Department of Psychiatry, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada; Douglas Research Centre, Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada; Ludmer Centre for Neuroinformatics and Mental Health, McGill University, Montreal, QC, Canada. Electronic address: patricia.silveira@mcgill.ca.
Jazyk: angličtina
Zdroj: Appetite [Appetite] 2025 Jan 01; Vol. 204, pp. 107762. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1016/j.appet.2024.107762
Abstrakt: Insulin receptors, located in brain regions associated with reward sensitivity and decision-making, facilitate insulin action in the brain, modulating intracellular signaling cascades, gene expression, and neural activity. Here, we tested if variations in the expression of the insulin receptor gene network in the prefrontal cortex (PFC) and striatum (STR) moderate the association between early life adversity and eating behaviour in childhood and if this moderation is sex-specific. Participants from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) and Basal Influences on the Baby's Development (BIBO) were included as two independent cohorts. A biologically-informed polygenic score reflecting functional variation of the mesocorticolimbic insulin receptor gene network was created by using insulin receptor co-expression data from the PFC and STR in mice, and validated in humans through filtering by homologous expression in PFC using well-known databases. Early life adversity exposure was measured as a composite score. Eating behaviour was characterized using the Child Eating Behaviour Questionnaire administered to mothers of children aged 4 and 6 years in MAVAN, and 6 years in BIBO. We found that only in those with high expression of the mesocorticolimbic insulin receptor gene network a higher early adversity score associated with a higher desire to drink in 4-year boys and 6-year girls, as well as a higher food approach score and food approach/food avoidance ratio in 4-year girls. Also, a higher early life adversity was associated with higher food responsiveness, food approach score and food approach/food avoidance ratio at 6 years in the MAVAN full sample. The moderation observed on desire to drink was partially replicated in BIBO children aged 6 years. Identifying individual differences in response to early adversity may help to prioritize individuals at high risk for long-term disease and design suitable interventions.
Competing Interests: Declaration of competing interest The authors report there are no competing interests to declare.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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