Predicting radiotoxic effects after BNCT for brain cancer using a novel dose calculation model.

Autor: Dattoli Viegas AM; División Física Computacional y Biofísica de las Radiaciones, Comisión Nacional de Energía Atómica (CNEA), Av. General Paz 1499, B1650KNA, San Martín, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2270, C1425FQD, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: anadattoli@cnea.gob.ar., Carando D; Departamento de Matemática, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, and IMAS (UBA-CONICET), Pabellón I, Ciudad Universitaria, C1428EHA, Buenos Aires, Argentina. Electronic address: dcarando@dm.uba.ar., Koivunoro H; Neutron Therapeutics, 1 Industrial Drive, Danvers, Massachusetts (01923), United States; Department of Oncology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, P.O.B. 180, FIN-00029, Helsinki, Finland. Electronic address: hanna.koivunoro@nt-bnct.com., Joensuu H; Department of Oncology, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, P.O.B. 180, FIN-00029, Helsinki, Finland. Electronic address: heikki.joensuu@hus.fi., González SJ; División Física Computacional y Biofísica de las Radiaciones, Comisión Nacional de Energía Atómica (CNEA), Av. General Paz 1499, B1650KNA, San Martín, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Godoy Cruz 2270, C1425FQD, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: srgonzal@cnea.gov.ar.
Jazyk: angličtina
Zdroj: Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2024 Dec; Vol. 128, pp. 104840. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1016/j.ejmp.2024.104840
Abstrakt: Purpose: The normal brain is an important dose-limiting organ for brain cancer patients undergoing radiotherapy. This study aims to develop a model to calculate photon isoeffective doses (D IsoE ) to normal brain that can explain the incidence of grade 2 or higher somnolence syndrome (SS⩾2) after Boron Neutron Capture Therapy (BNCT).
Methods: A D IsoE model was constructed to find the reference photon dose that equals the Normal Tissue Complication Probability (NTCP) of the absorbed dose from BNCT. Limb paralysis rates from the rat spinal cord model exposed to conventional or BNCT irradiation were used to determine model parameters. NTCP expressions for both irradiations were constructed based on Lyman's model accordingly. D IsoE values were calculated for BNCT treatments performed in Finland and USA. An equivalent uniform dose (EUD) based on peak and average whole-brain doses and treatment fields was also introduced. Combining D IsoE and EUD models, a dose-response curve for SS⩾2 in BNCT patients was constructed and compared to conventional radiotherapy outcomes.
Results: The D IsoE model reveals higher than expected photon-equivalent doses in the brain, indicating the need to modify standard dose calculation methods. Neither peak dose nor average whole-brain dose alone predicts SS⩾2 development. However, the dose-response curve derived from combining D IsoE and EUD models effectively explains the incidence of SS⩾2 after BNCT.
Conclusions: The introduced D IsoE and EUD models predict the incidence of somnolence syndrome after BNCT. The first dose-response relationship for SS⩾2 derived entirely from brain tumour patients treated with BNCT, consistent with photon radiotherapy responses, is presented.
Competing Interests: Declaration of competing interest None
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: