Triterpenoid saponins from the fruit pulp of Tetrapleura tetraptera (Fabaceae).

Autor: Chi GF; Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.; H.E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Khan S; H.E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan., Kuete JRN; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Matieta VY; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Ombito JO; Department of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana., Tamfu AN; School of Chemical Engineering and Mineral Industries, University of Ngaoundere, Cameroon., Megaptche JF; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Chongong MA; Department of Chemistry, Faculty of Science, University of Bamenda, Bamenda, Cameroon., Demissie TB; Department of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana., Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Shaheen F; H.E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2024 Nov 09, pp. 1-13. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1080/14786419.2024.2426072
Abstrakt: Tetrapleura tetraptera fruit, used as spice in West Africa was studied chemically; five previously undescribed triterpenoid saponins 1 - 5 and four known compounds 6 - 9 were isolated from the n -Butanol fraction. The chemical structures of all nine isolates were determined by comprehensive analysis of HRMS, 1D & 2D NMR experiments and by comparison with data in the literature. All nine compounds were evaluated for antibacterial activity by the broth microdilution through the rapid p -iodonitrotetrazolium chloride (INT) colorimetric technique. The results showed that only compounds 5 (MIC = 64 µg/mL against P. aeruginosa and P. stuartii ) and 8 (MIC = 64 µg/mL against E. coli ) exhibited moderate antibacterial activity. The rest of the compounds displayed weak antibacterial activity against the tested organisms. Molecular docking studies was used to comprehend antibacterial activities.
Databáze: MEDLINE