Connecting the changing trace elements spectrum and survival in sarcoma: a pilot study.

Autor: Collet L; Breast Cancer Translational Research Laboratory, Department of Medical Oncology, Institut Jules Bordet, Brussels, Belgium.; Department of Medical Oncology, Institut Jules Bordet, Brussels, Belgium.; Department of Medical Oncology, Centre Leon Berard, Lyon, France., Telouk P; Ecole Normale Supérieure de Lyon and CNRS UMR 5276, Lyon, France., Albarede F; Ecole Normale Supérieure de Lyon and CNRS UMR 5276, Lyon, France., Girodet M; Department of Human and Social Sciences, Centre Léon-Bérard, Lyon, France., Maqua C; Medical Practice Evaluation and Networks Team, Centre Léon Bérard, Lyon, France., Rogasik M; Medical Practice Evaluation and Networks Team, Centre Léon Bérard, Lyon, France., Ducimetière F; Medical Practice Evaluation and Networks Team, Centre Léon Bérard, Lyon, France., Tabone-Eglinger S; Biological Resources Center, Department of Biopathology, Centre Léon Bérard, Lyon, France., Brahmi M; Department of Medical Oncology, Centre Leon Berard, Lyon, France., Dufresne A; Department of Medical Oncology, Centre Leon Berard, Lyon, France., Thomas DM; Garvan Institute of Medical Research, Sydney, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, 2010, Australia., Ballinger ML; Garvan Institute of Medical Research, Sydney, 2010, Australia.; St Vincent's Clinical School, University of New South Wales, Sydney, 2010, Australia., Blay JY; Department of Medical Oncology, Centre Leon Berard, Lyon, France., Ray-Coquard I; Department of Medical Oncology, Centre Leon Berard, Lyon, France. isabelle.ray-coquard@lyon.unicancer.fr.
Jazyk: angličtina
Zdroj: Metabolomics : Official journal of the Metabolomic Society [Metabolomics] 2024 Nov 09; Vol. 20 (6), pp. 129. Date of Electronic Publication: 2024 Nov 09.
DOI: 10.1007/s11306-024-02178-z
Abstrakt: Objectives: While some metals have been reported as carcinogens or potential carcinogens, only few modern-standard datasets including a large number of elements are available. The present analysis established a first trace elements spectrum by relating the concentration of metals and trace elements in the serum of sarcoma patients with survival data.
Methods: Patients with sarcoma and controls were retrospectively selected from the International Sarcoma Kindred Study database (ISKS). As part of the ISKS study, blood samples were prospectively collected at the Leon Bérard Cancer Center from February 2012 to July 2019. Stable specimens and copper isotopes ( 65 Cu/ 63 Cu) were analyzed using Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer (ICP-MS) and the Multicollector MC-ICP-MS Nu Plasma HR 500. Wilcoxon rank sum test, log-rank test, and multivariate Cox regression models were used for statistics.
Results: In total, 151 patients and 59 healthy controls were included. At the time of blood sample collection, 62% of patients had locally advanced or metastatic disease. Copper (Cu), copper/zinc (Cu/Zn) and potassium/rubidium (K/Rb) ratio were significantly higher in patients compared to controls and were also significantly higher in patients with advanced compared to early-stage sarcoma. Whereas S and Se were significantly correlated in patients, no correlation was observed in controls. Importantly, levels of K, Rb, Se, Fe, P, Si, S, δ 65 Cu, Cu, S/Se and Cu/Zn ratio were independently associated with overall survival.
Conclusions: These results depict the metallomic spectrum in sarcoma and highlight substantial variation associated with survival, enhancing our understanding of sarcoma's biology.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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