| Autor: |
Sianipar NF; Biotechnology Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia.; Food Biotechnology Research Center, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia., Muflikhati Z; Food Biotechnology Research Center, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia., Mangindaan D; Waste-Food-Environmental Nexus Research Interest Group, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia.; Civil Engineering Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia.; Professional Engineering Program Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia., Assidqi K; Biotechnology Department, Faculty of Engineering, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia.; Food Biotechnology Research Center, Bina Nusantara University, Jl. KH Syahdan No. 9, Jakarta 11480, Indonesia. |
| Abstrakt: |
Tocopherols, potent bioactive compounds with anticancer properties, remain understudied in herbal medicinal plants, presenting a significant knowledge gap in the field of natural anticancer agents. This review evaluates tocopherol-containing plants for their anticancer potential, analyzing Scopus publications from 2016 to 2024. Fifteen herbal medicinal plants were identified as promising candidates, including Bulbine anguistifolia Poelln, Punica granatum L., Moringa oleifera , Kigelia pinnata , and Typhonium flagelliforme Lodd. The review explores tocopherols' anticancer mechanisms, including apoptosis induction and cell cycle arrest. Factors influencing tocopherols' anticancer effects are examined, such as their forms (α, β, γ, δ), concentrations, plant parts utilized, and their stability in various plants. Additionally, emerging research on semi-synthetic tocopherol derivatives is analyzed, highlighting their potential as adjuvants in chemotherapy and their role in enhancing drug delivery and reducing side effects. This comprehensive analysis aims to advance the development of plant-based anticancer pharmaceuticals and improve cancer treatment strategies. By elucidating the mechanisms and potential of tocopherol-containing plants, this review provides a foundation for future research in plant-based anticancer therapies. It emphasizes the need for further investigation into these plants' anticancer properties, potentially leading to novel, more effective, and less toxic cancer therapies. The findings presented here contribute to a nuanced understanding of how tocopherol-containing plants can be leveraged in the development of future anticancer drugs. |
