| Autor: |
Chen X; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Cao Y; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Ye K; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Liu Y; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Chi F; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Niu Y; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Lu D; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Zhao B; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Chen L; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China., Zheng X; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China.; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease by Henan and Education Ministry of P.R. China, Zhengzhou 450046, China., Feng W; School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.; The Engineering and Technology Center for Chinese Medicine Development of Henan Province China, Zhengzhou 450046, China.; Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease by Henan and Education Ministry of P.R. China, Zhengzhou 450046, China. |
| Abstrakt: |
Seven new alkaloids [ 1 , (±)- 2 , (±)- 3 , 4 , and 5 ] and one new natural product ( 6 ), along with eight known analogues, were isolated from the tubers of Pinellia pedatisecta Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)- 3 , 6 , and 9 exhibited significantly protective effects against A β 25-35 -induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP). |
