A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital.

Autor: Trusculescu AA; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.; Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania., Ancusa VM; Department of Computer and Information Technology, Automation and Computers Faculty, 'Politehnica' University of Timis, Vasile Pârvan Blvd, no. 2, 300223 Timisoara, Romania., Pescaru CC; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.; Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania., Wellmann N; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.; Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania.; Doctoral School, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania., Fira-Mladinescu C; Hygiene Division, Department of Microbiology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Victor Babes Street, no. 16, 300226 Timisoara, Romania.; Center for Study in Preventive Medicine, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania., Oancea CI; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.; Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania., Fira-Mladinescu O; Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.; Pulmology University Clinic, Clinical Hospital of Infectious Diseases and Pneumophysiology Dr. Victor Babeș Timișoara, Gheorghe Adam Street, no. 13, 300310 Timisoara, Romania.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Nov 04; Vol. 13 (21). Date of Electronic Publication: 2024 Nov 04.
DOI: 10.3390/jcm13216615
Abstrakt: Background : Status asthmaticus is a severe, life-threatening asthma exacerbation requiring urgent medical intervention. This study aims to examine its epidemiology in Timis County, Romania, over 11 years. Methods : A retrospective analysis was conducted using hospital records from 2013 to 2023, focusing on demographic, geospatial, and temporal distributions. Network analysis of the recorded comorbidities was used to identify phenotypic clusters among patients. Results : Females and older adults were disproportionately affected. Several triggers and geospatial patterns were identified. Five phenotypic clusters were determined: two in the T2-high endotype, two in T2-low, and a mixed one. Conclusions : The findings highlight the need for personalized asthma management strategies and public healthcare interventions in Timiș County, addressing specific demographic and geospatial factors. This study also provides a valuable reference for similar regions.
Databáze: MEDLINE
Nepřihlášeným uživatelům se plný text nezobrazuje