Design Principles and Applications of Fluorescent Kinase Inhibitors for Simultaneous Cancer Bioimaging and Therapy.

Autor: Ganai AM; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece., Vrettos EI; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece., Kyrkou SG; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece., Zoi V; Neurosurgical Institute, University of Ioannina, 45110 Ioannina, Greece., Khan Pathan T; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Karpoormath R; Department of Pharmaceutical Chemistry, Discipline of Pharmaceutical Sciences, College of Health Sciences, University of KwaZulu-Natal (Westville), Durban 4000, South Africa., Bouziotis P; Institute of Nuclear and Radiological Science and Technology, Energy and Safety (INRASTES), National Center for Scientific Research 'Demokritos', 15310 Athens, Greece., Alexiou GA; Neurosurgical Institute, University of Ioannina, 45110 Ioannina, Greece., Kastis GA; Institute of Nuclear and Radiological Science and Technology, Energy and Safety (INRASTES), National Center for Scientific Research 'Demokritos', 15310 Athens, Greece.; Mathematics Research Center, Academy of Athens, 11527 Athens, Greece., Protonotarios NE; Institute of Nuclear and Radiological Science and Technology, Energy and Safety (INRASTES), National Center for Scientific Research 'Demokritos', 15310 Athens, Greece.; Mathematics Research Center, Academy of Athens, 11527 Athens, Greece., Tzakos AG; Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.; Institute of Materials Science and Computing, University Research Center of Ioannina (URCI), Ioannina 45110, Greece.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Oct 30; Vol. 16 (21). Date of Electronic Publication: 2024 Oct 30.
DOI: 10.3390/cancers16213667
Abstrakt: Kinase inhibitors are potent therapeutic agents in cancer treatment, but their effectiveness is frequently restricted by the inability to image the tumor microenvironment. To address this constraint, kinase inhibitor-fluorophore conjugates have emerged as promising theranostic agents, allowing for simultaneous cancer diagnosis and treatment. These conjugates are gaining attention for their ability to visualize malignant tissues and concurrently enhance therapeutic interventions. This review explores the design principles governing the development of multimodal inhibitors, highlighting their potential as platforms for kinase tracking and inhibition via bioimaging. The structural aspects of constructing such theranostic agents are critically analyzed. This work could shed light on this intriguing field and provide adequate impetus for developing novel theranostic compounds based on small molecule inhibitors and fluorophores.
Databáze: MEDLINE
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