| Autor: |
D'Onghia M; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Mendonça-Sanches M; Dermatology Unit, Champalimaud Clinical Centre, Champalimaud Foundation, 1400-038 Lisbon, Portugal., Erasti M; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Cartocci A; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Calabrese L; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Sirchio A; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Tognetti L; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Batsikosta A; Department of Medical Biotechnology, Pathological Anatomy Section, University of Siena, 51300 Siena, Italy., Lazzi S; Department of Medical Biotechnology, Pathological Anatomy Section, University of Siena, 51300 Siena, Italy., Suppa M; Department of Dermatology, Hôpital Erasme, Université Libre de Bruxelles, 1050 Bruxelles, Belgium., Soglia S; Dermatology Department, University of Brescia, ASST Spedali Civili di Brescia, 25123 Brescia, Italy., Malvehy J; Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, 08007 Barcelona, Spain.; CIBER de Enfermedades Raras, Instituto de Salud Carlos III, 08034 Barcelona, Spain., Perez-Anker J; Melanoma Unit, Hospital Clinic Barcelona, University of Barcelona, 08007 Barcelona, Spain.; CIBER de Enfermedades Raras, Instituto de Salud Carlos III, 08034 Barcelona, Spain., Cencini E; Department of Medical, Surgical and Neurological Sciences, Hematology Section, University of Siena, 53100 Siena, Italy., Fabbri A; Department of Medical, Surgical and Neurological Sciences, Hematology Section, University of Siena, 53100 Siena, Italy., Rubegni P; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy., Cinotti E; Dermatology Unit, Department of Medical, Surgical and Neurological Sciences, University of Siena, 51300 Siena, Italy. |
| Abstrakt: |
Background/Objectives: Primary cutaneous lymphomas (PCL) are a heterogeneous group of non-Hodgkin lymphomas arising from malignant T (CTCL) or B (CBCL) cells, often mimicking other skin conditions. Recently, non-invasive diagnostic imaging modalities, including dermoscopy, Reflectance Confocal Microscopy (RCM), and Line-field Optical Coherence Tomography (LC-OCT), have become increasingly important, supporting clinicians in clinical practice. Hence, our study aimed to describe dermoscopic, RCM, and LC-OCT features of PCL and to explore their role in PCL management. Methods : Between December 2022 and January 2024, 40 lesions of 25 patients with PCL were retrospectively analyzed at the Dermatologic Unit of the University of Siena, Italy. Predefined dermoscopic, LC-OCT, and RCM criteria were assessed and their frequencies were calculated. Results: At dermoscopy, CTCL lesions were characterized by pinkish structureless areas (58,6%) and homogeneous distributed dotted vessels (35,7%), whereas 57.1% of CBCL presented with orange-yellow structureless areas. Considering CTCL, lymphocytes in the epidermis, dermal-epidermal junction, and dermis were detected by LC-OCT in 73.1%, 66.7%, and 51.9% and by RCM in 72.2%, 55.6%, and 61.1% of cases, respectively. The detection of lymphocytes was more precise using RCM than LC-OCT in CTCL ( p < 0.001). Dermal infiltration of medium-reflective cells was visible in 80% and 40% of CBCL cases by LC-OCT and RCM, respectively. Conclusions : Non-invasive imaging techniques may support clinicians in managing PCL; however, further studies are mandatory in this field. |
