Targeting the Ubiquitin Proteasome System to Combat Influenza A Virus: Hijacking the Cleanup Crew.

Autor: Anang V; Pulmonary, Critical Care Medicine, and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Antonescu L; Pulmonary, Critical Care Medicine, and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Nho R; Pulmonary, Critical Care Medicine, and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Soni S; Pulmonary, Critical Care Medicine, and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA., Mebratu YA; Pulmonary, Critical Care Medicine, and Sleep Medicine, Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2024 Nov; Vol. 34 (6), pp. e70005.
DOI: 10.1002/rmv.70005
Abstrakt: Influenza A virus (IAV) remains a significant global public health threat, causing substantial illness and economic burden. Despite existing antiviral drugs, the emergence of resistant strains necessitates alternative therapeutic strategies. This review explores the complex interplay between the ubiquitin proteasome system (UPS) and IAV pathogenesis. We discuss how IAV manipulates the UPS to promote its lifecycle, while also highlighting how host cells utilise the UPS to counteract viral infection. Recent research on deubiquitinases as potential regulators of IAV infection is also addressed. By elucidating the multifaceted role of the UPS in IAV pathogenesis, this review aims to identify potential targets for novel therapeutic interventions.
(© 2024 The Author(s). Reviews in Medical Virology published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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