Adipose tissue-gut microbiome crosstalk in inflammation and thermogenesis.

Autor: Mauney EE; Joslin Diabetes Center, Boston, MA 02215, USA; Massachusetts General Hospital for Children, Pediatric Gastroenterology and Nutrition Program, Boston, MA 02114, USA., Wibowo MC; Joslin Diabetes Center, Boston, MA 02215, USA., Tseng YH; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address: Yu-Hua.Tseng@joslin.harvard.edu., Kostic AD; Joslin Diabetes Center, Boston, MA 02215, USA. Electronic address: Aleksandar.Kostic@joslin.harvard.edu.
Jazyk: angličtina
Zdroj: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1016/j.tem.2024.10.004
Abstrakt: Previously characterized as inert fat depots, adipocytes are now recognized as dynamic mediators of inflammatory tone, metabolic health, and nutrient homeostasis. As endocrine organs, specialized depots of adipose tissue engage in crosstalk between the gut, liver, pancreas, and brain to coordinate appetite, thermogenesis, and ultimately body weight. These functions are tightly linked to the inflammatory status of adipose tissue, which is in turn influenced by the health of the gut microbiome. Here, we review recent findings linking specific gut microbes and their secreted factors, including recently identified elements such as bacterial extracellular vesicles, to the functional status of adipocytes. We conclude that further study may generate novel approaches for treating obesity and metabolic disease.
Competing Interests: Declaration of interests E.M. receives research funding from Tryp Therapeutics (unrelated to the content of this manuscript.). A.K. is a founder of FitBiomics, Inc. and has a patent pending related to bacterial extracellular vesicles (US Application No. 18/640,699). Y.-H.T. has no conflicts of interest to declare.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: