Clinical parameters of death and heart failure hospitalization in biventricular systolic dysfunction assessed via cardiac magnetic resonance.

Autor: Al'Aref SJ; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Gautam N; Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Mansour M; Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Alqaisi O; Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Tarun T; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Devabhaktuni S; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Atreya A; Department of Medicine, Division of Cardiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA., Abete R; Department of Cardiology, Policlinico di Monza, Monza, Italy., Aquaro GD; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Baggiano A; Centro Cardiologico Monzino IRCCS, Milan, Italy; Cardiovascular Section, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy., Barison A; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Bogaert J; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Camastra G; Cardiac Department, Vannini Hospital Rome, Rome, Italy., Carigi S; Department of Cardiology, Infermi Hospital, Rimini, Italy., Carrabba N; Cardiovascular and Thoracic Department of Careggi Hospital, Florence, Italy., Casavecchia G; Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy., Censi S; Maria Cecilia Hospital, GVM Care & Research, Cotignola, RA, Italy., Cicala G; Department of Diagnostic, Parma University Hospital, Via Gramsci, Parma, Italy., De Cecco CN; Division of Cardiothoracic Imaging, Emory University, Atlanta, GA, USA., De Lazzari M; Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy., Di Giovine G; Department of Cardiology, Policlinico di Monza, Monza, Italy., Calo L; Cardiology Department, Policlinico Casilino, Rome, Italy., Dobrovie M; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Focardi M; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy., Fusini L; Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Electronics, Information and Bioengineering, Politecnico di Milano, Italy., Gaibazzi N; Department of Cardiology, Azienda Ospedaliero- Universitaria, Parma, Italy., Gismondi A; Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy., Gravina M; Department of Radiology, University of Foggia, Foggia, Italy., Guglielmo M; Department of Cardiology, Division of Heart and Lungs, Utrecht University, Utrecht, the Netherlands; Department of Cardiology, Haga Teaching Hospital, The Hague, Netherlands., Lanzillo C; Cardiology Department, Policlinico Casilino, Rome, Italy., Lombardi M; Multimodality Cardiac Imaging Section, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy., Lorenzoni V; Institute of Management, Scuola Superiore Sant'Anna, Pisa, Italy., Lozano-Torres J; Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Bellaterra, Spain; CIBER-CV, Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Margonato D; Department of Cardiology, Policlinico di Monza, Monza, Italy., Martini C; Department of Diagnostic, Parma University Hospital, Via Gramsci, Parma, Italy; Department of Medicine and Surgery, University of Parma, Parma, Italy., Marzo F; Department of Cardiology, Infermi Hospital, Rimini, Italy., Masci PG; School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK., Masi A; De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Moro C; Department of Cardiology, ASST Monza, P.O. Desio, Italy., Muscogiuri G; Istituto Auxologico Italiano-IRCCS, Milan, Italy; University of Milan Bicocca, Milan, Italy., Mushtaq S; Centro Cardiologico Monzino IRCCS, Milan, Italy., Nese A; Dipartimento Neuro-Cardiovascolare, Ospedale Ca' Foncello Treviso, Treviso, Italy., Palumbo A; Department of Diagnostic, Parma University Hospital, Via Gramsci, Parma, Italy., Pavon AG; Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland., Pedrotti P; De Gasperis' Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy., Marra MP; Department of Cardiac, Thoracic, Vascular Sciences and Public Health University of Padua Medical School, Padova, Italy., Pradella S; Department of Radiology, Careggi Hospital, Florence, Italy., Presicci C; Department of Diagnostic, Parma University Hospital, Via Gramsci, Parma, Italy., Rabbat MG; Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA; Edward Hines Jr. VA Hospital, Hines, IL, United States of America., Raineri C; Department of Cardiology, Citta` della salute e della Scienza - Ospedale Molinette, Turin, Italy., Rodriguez-Palomares JF; Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Bellaterra, Spain; CIBER-CV, Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Sbarbati S; Radiology Department, Vannini Hospital Rome, Rome, Italy., Schoepf UJ; Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, SC, USA., Squeri A; Maria Cecilia Hospital, GVM Care & Research, Cotignola, RA, Italy., Sverzellati N; Department of Medicine and Surgery, University of Parma, Parma, Italy., Symons R; Department of Radiology, University Hospital Leuven, Leuven, Belgium., Tat E; Division of Cardiology, Loyola University of Chicago, Chicago, IL, USA., Timpani M; UOC Radiologia, Ospedale 'F. Spaziani', Frosinone, Italy., Todiere G; U.O.C. Risonanza Magnetica per Immagini, Fondazione G. Monasterio CNR-Regione Toscana Pisa, Pisa, Italy., Valentini A; Department of Radiology, Fondazione IRCCS Policlinico S.Matteo, Pavia, Italy., Varga-Szemes A; UOC Radiologia, Ospedale 'F. Spaziani', Frosinone, Italy., Volpe A; Centro Cardiologico Monzino IRCCS, Milan, Italy., Guaricci AI; University Cardiology Unit, Interdisciplinary Department of Medicine, University of Bari Aldo Moro, Bari, Italy., Schwitter J; Cardiovascular Department, CMR Center, University Hospital Lausanne, CHUV, Lausanne, Switzerland; Faculty of Biology and Medicine, Lausanne University, UniL, Lausanne, Switzerland; Faculty of Medicine and Biology, University of Lausanne, UniL, Lausanne, Switzerland., Pontone G; Centro Cardiologico Monzino IRCCS, Milan, Italy; Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, University of Milan, Milan, Italy; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. Electronic address: gianluca.pontone@ccfm.it.
Jazyk: angličtina
Zdroj: International journal of cardiology [Int J Cardiol] 2024 Nov 07; Vol. 419, pp. 132709. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1016/j.ijcard.2024.132709
Abstrakt: Aims: While factors associated with adverse events are well elucidated in setting of isolated left ventricular dysfunction, clinical and imaging-based prognosticators of adverse outcomes are lacking in context of biventricular dysfunction. The purpose of this study was to establish role of clinical variables in prognosis of biventricular heart failure (HF), as assessed by cardiac magnetic resonance imaging.
Methods: Study cohort consisted of 840 patients enrolled in DERIVATE registry with coexisting CMR-derived right ventricular (RV) and left ventricular (LV) dysfunction, as defined by RV and LV ejection fractions ≤45 % and ≤ 50 %, respectively. The primary objective was to identify factors associated with adverse long-term outcomes, defined as composite of all-cause death and HF hospitalizations (DHFH). Kaplan-Meir curves were plotted for survival analysis. Cox proportional hazard models were constructed to estimate adjusted hazard ratios (aHRs) and associated 95 % confidence intervals for clinical variables and their correlation with adverse events.
Results: Mean age was 61.0 years; 83.1 % were male, 26.6 % had diabetes mellitus (DM), and 45.9 % had non-ischemic cardiomyopathy. At median follow-up of 2 years, DHFH occurred in 32.5 % of the cohort. Kaplan-Meir analysis showed higher rate of DHFH in patients with DM (35.2 % vs. 22.6 %, p < 0.001). Multivariate Cox regression analysis showed that DM was independently associated with DHFH (aHR 1.61 [95 % CI: 1.15-2.25]; p = 0.003). Importantly, ACE-inhibitor/ARB usage in patients with DM was associated with significant reduction in DHFH (aHR 0.53 [95 % CI: 0.31-0.90]; p = 0.02).
Conclusion: In patients with biventricular HF, DM was a strong predictor of DHFH, with ACE-inhibitor/ARB usage having cardioprotective effect.
Competing Interests: Declaration of competing interest Subhi J. Al’Aref is supported by NIH: National Institutes of Health, USA 2R01 HL12766105 & 1R21 EB030654 and receives royalty fees from Elsevier. Carlo De Cecco received grant from Siemens. Gianluca Pontone received institutional fees by General Electric, Bracco, Heartflow, Medtronic, Bayer, Bhoeringher. Juerg Schwitter received research support by Bayer Healthcare Switzerland. U. Joseph Schoepf received grant by Astellas, Bayer, General Electric, and Siemens Healthcare, personal fees by Guerbet, speaking honorarium by Heartflow. Akos Varga-Szemes received grant from Siemens Healthcare and personal fees from Elucid Bioimaging. The other authors have no conficts of interestes relevant to this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: