The triglyceride-glucose index, blood glucose levels, and metabolic syndrome are associated with all-cause mortality in obesity.

Autor: Pontiroli AE; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy. Electronic address: antonio.pontiroli@unimi.it., Centofanti L; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy., Zakaria AS; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy., Cerutti S; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy., Dei Cas M; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy., Paroni R; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy., La Sala L; Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milano, Italy; IRCCS MultiMedica, Sesto San Giovanni, Milano, Italy. Electronic address: lucia.lasala@multimedica.it., Tagliabue E; IRCCS MultiMedica, Sesto San Giovanni, Milano, Italy., Magnani S; IRCCS MultiMedica, Sesto San Giovanni, Milano, Italy., Folli F; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Italy. Electronic address: franco.folli@unimi.it.
Jazyk: angličtina
Zdroj: Diabetes & metabolic syndrome [Diabetes Metab Syndr] 2024 Oct; Vol. 18 (10), pp. 103146. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1016/j.dsx.2024.103146
Abstrakt: Background: The Triglyceride-Glucose Index (TYG) has been proposed as a prognostic index for mortality in the general population, in T2DM, and in patients with cardiovascular diseases. However, data on the respective predictive roles of TYG, glucose tolerance (GT), and metabolic syndrome (MS) for mortality in obesity are lacking.
Methods: We analyzed 1359 obese patients (371 men and 988 women), aged 44.1 ± 12.64 years, followed for 14.3 ± 4.44 years. They were subdivided according to glucose tolerance, in normal glucose tolerance (NGT), impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM). We analyzed the risk of death associated with blood glucose (BG) quartiles, TYG quartiles and MS quartiles. Cox proportional-hazard models were used to evaluate the risk of death associated with independent variables that were highly statistically significant at univariate analysis.
Results: Different degrees of glucose tolerance were associated with a progressive deterioration of clinical outcomes, and increased all-cause mortality (6.3 %, 10.1 %, and 20.4 %, respectively). In all groups, age and male sex were associated with increased mortality. Higher TYG or TYG quartiles, BG or BG quartiles, and MS or MS quartiles were all associated with increased all-cause mortality in the whole cohort.
Conclusion: TYG, blood glucose and MS are risk factors for mortality in obesity, with a progressively stronger value in IFG and T2DM as compared to NGT.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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