Characterizing metabolome signature of colostrum, transition and mature milk of indigenous cows (Bos indicus) adapted to high altitude environment of Leh-Ladakh.

Autor: Amarjeet; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Kumar U; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Sodhi M; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Kumar D; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Vivek P; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Niranjan SK; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Kataria RS; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Kumar S; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Sharma M; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Tiwari M; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Aggarwal RAK; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Bharti VK; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Iqbal M; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Rabgais S; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Kumar A; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Chanda D; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India., Mukesh M; ICAR-National Bureau of Animal Genetic Resources, Karnal, Haryana 132001, India. Electronic address: manishi.mukesh@icar.gov.in.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2025 Feb 01; Vol. 464 (Pt 3), pp. 141767. Date of Electronic Publication: 2024 Oct 24.
DOI: 10.1016/j.foodchem.2024.141767
Abstrakt: This study has identified 46 metabolites in colostrum, transition milk and mature milk of unique indigenous high altitude adapted Ladakhi cows using 1D 1H 800 MHz NMR spectroscopy. The multivariate analysis revealed that UDP-galactose, UDP-glucose, citrate, creatine phosphate, myo-inositol, lactose, 2-oxoglutarate, valine, maltose, leucine, dimethylamine, and choline with high VIP scores could differentiate the colostrum, transition and mature milk in separate clusters. Highly enriched metabolites in colostrum such as UDP-galactose, UDP-glucose play crucial roles in cell growth, differentiation, and defense responses. Similarly, the presence of branched chain amino acids in colostrum could be linked to mammary gland development, N-acetylglucosamine, N-acetyl carnitine, choline etc. in high concentration in colostrum l might be helping in growth and development of neonatal calves of Ladakhi cows under hypoxia environment. Overall, this study has helped to characterize the metabolomic signatures of milk/colostrum of Ladakhi cows adapted to high altitude and cold desert of Leh-Ladakh.
Competing Interests: Declaration of competing interest All authors declare that there's no financial/personal interest or belief or potential conflict that could affect the objectivity. Further, there are no competing interests exist amongst authors.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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