High dose of liraglutide impairs renal function in female hypertensive rats.

Autor:	Firmino FT; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Peixoto P; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Batista TJ; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., da Silva Escouto L; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Brasil GA; Postgraduate program in Pharmaceutical Sciences, Vila Velha University, ES, Brazil., Couto MDR; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil., Ferreira de Melo Júnior A; NOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas (NMS/FCM), Universidade NOVA de Lisboa, 1156-056 Lisboa, Portugal.; Centro Clínico e Académico de Lisboa, 1156-056 Lisboa, Portugal., Bissoli NS; Postgraduate Program in Physiological Sciences, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.
DOI:	10.1097/FJC.0000000000001649
Abstrakt:	Glucagon-like peptide-1 (GLP-1) receptor agonists exhibit beneficial cardiovascular effects. However, the renal effects of different doses of liraglutide in an essential hypertension model have not yet been investigated. SHR female rats were treated for 30 days, twice a day, with saline (control) or liraglutide at low (0.06 mg/kg, LL) and high (0.6 mg/kg, LH) doses. Volume intake and excretion were monitored for a period of 24h. In renal tissue, nitrite-NO2-, nitrate-NO3-, advanced protein oxidation products-AOPP, collagen deposition, creatinine (Cr), urea (U), sodium, and potassium were analyzed. liraglutide reduced body weight gain in both groups. However, in the high dose, it increased urinary volume excretion and sodium/potassium ratio. Both doses reduced the urinary U/Cr ratio and LH increased the serum U/Cr ratio. AOPP was reduced only in LL. LH augmented collagen and early markers of kidney injury (blood urea nitrogen-BUN, BUN/Cr). LH increased NO3-, reduced NO2-, and caused an aberrant increase in GFR. Both doses' effects were independent of blood pressure and glycemic control. liraglutide appears to have distinct effects on the hypertensive female kidney depending on the dose, with higher doses impairing kidney function. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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