| Autor: |
Urbańska W; Department of Internal Medicine, Infectious Diseases and Allergology, Military Institute of Medicine, National Research Institute, Szaserów 128, 04-141 Warsaw, Poland., Szymański Ł; Department of Molecular Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, 05-552 Magdalenka, Poland., Lewicka A; Military Centre of Preventive Medicine, Lesna 4D, Modlin, 05-100 Nowy Dwor Mazowiecki, Poland., Ciepielak M; Department of Regenerative Medicine, Maria Sklodowska-Curie National Research Institute of Oncology, WK Roentgena 5, 02-781 Warsaw, Poland., Kostrzeńska-Sęk K; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Pl. Żelaznej Bramy 10, 00-136 Warsaw, Poland., Chciałowski A; Department of Internal Medicine, Infectious Diseases and Allergology, Military Institute of Medicine, National Research Institute, Szaserów 128, 04-141 Warsaw, Poland., Lewicki S; Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Pl. Żelaznej Bramy 10, 00-136 Warsaw, Poland. |
| Abstrakt: |
Wasp venom allergy can trigger severe allergic reactions, and predicting these acute responses remains challenging. This study evaluates the utility of immune system indexes, particularly the eosinophil-basophil/lymphocyte (EB/LR) and eosinophil-basophil-platelet/lymphocyte (EBP/LR) ratios, in assessing the severity of allergic reactions in patients with wasp venom allergy. A total of 61 patients with confirmed wasp venom allergy were categorized according to the Mueller scale, which classifies the severity of allergic reactions. Blood samples were analyzed for total and specific IgE levels alongside a range of hematological and biochemical parameters. This study found significant differences in the EB/LR and EBP/LR indexes between patients with mild (Mueller I-II) and severe (Mueller III-IV) allergic reactions, with higher values indicating more severe responses. However, no significant differences were observed in other immune indexes, such as the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, and systemic inflammatory response index, as well as in additional blood parameters. These findings suggest that the EB/LR and EBP/LR ratios may serve as useful markers for predicting the severity of allergic reactions in patients with wasp venom allergy. This is the first study to establish such a link, although further research with larger cohorts is necessary to confirm these results and their potential application in clinical settings. |
