| Autor: |
Seo YJ; Department of Oral and Maxillofacial Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Institute of Medical Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea., Park JH; Department of Nutritional Science, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA., Byun JH; Department of Oral and Maxillofacial Surgery, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Institute of Medical Sciences, Gyeongsang National University, Jinju 52727, Republic of Korea.; Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Republic of Korea. |
| Jazyk: |
angličtina |
| Zdroj: |
Cells [Cells] 2024 Oct 28; Vol. 13 (21). Date of Electronic Publication: 2024 Oct 28. |
| DOI: |
10.3390/cells13211781 |
| Abstrakt: |
Osteoporosis is a common skeletal disease, primarily associated with aging, that results from decreased bone density and bone volume. This reduction significantly increases the risk of fractures in osteoporosis patients compared to individuals with normal bone density. Additionally, the bone regeneration process in these patients is slow, making complete healing difficult. Along with the decline in bone volume and density, osteoporosis is characterized by an increase in marrow adipose tissue (MAT), which is fat within the bone. In this altered bone microenvironment, osteoblasts are influenced by various factors secreted by adipocytes. Notably, saturated fatty acids promote osteoclast activity, inhibit osteoblast differentiation, and induce apoptosis, further reducing osteoblast formation. In contrast, monounsaturated fatty acids inhibit osteoclast formation and mitigate the apoptosis caused by saturated fatty acids. Leveraging these properties, we aimed to investigate the effects of overexpressing stearoyl-CoA desaturase 1 (SCD1), an enzyme that converts saturated fatty acids into monounsaturated fatty acids, on osteogenic differentiation and bone regeneration in both in vivo and in vitro models. Through this novel approach, we seek to develop a stem cell-based therapeutic strategy that harnesses SCD1 to improve bone regeneration in the adipocyte-rich osteoporotic environment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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