Diastereoselective Anomeric C(sp 3 )-H Cyclization Towards the Design of New Cyclophane-Braced Glycopeptides.

Autor: Bazzi S; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France., Hadj Mohamed A; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France.; Laboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, ENSTA, Institut Polytechnique de Paris, Palaiseau, France., Ryzhakov D; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France., Ghouilem J; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France., Beniddir MA; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France., Gandon V; Université Paris-Saclay, CNRS, ICMMO, 91400, Orsay, France., Messaoudi S; Université Paris-Saclay, CNRS, BioCIS, 91400, Orsay, France.; Laboratoire de Synthèse Organique, Ecole Polytechnique, CNRS, ENSTA, Institut Polytechnique de Paris, Palaiseau, France.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 08, pp. e202418057. Date of Electronic Publication: 2024 Nov 08.
DOI: 10.1002/anie.202418057
Abstrakt: Here we report a macrocyclization route towards the synthesis of glycophane peptides by a selective C-H arylation of the anomeric bond. This approach demonstrates the power of Pd-catalysis C-H activation to access unusual cyclic peptides.
(© 2024 The Author(s). Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: