Sex disparities in outcomes among hospitalizations for heart failure.

Autor: Appunni S; Government Medical College, Kozhikode, Kerala, India., Zhang Y; Baptist Health South Florida, Miami, FL, USA., Khosla AA; William Beaumont University Hospital, Royal Oak, MI, 48073, USA., Rubens M; Miami Cancer Institute, Baptist Health South Florida, Miami, FL, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.; Universidad Espíritu Santo, Samborondón, Ecuador., Giri AR; Department of Internal Medicine, Cleveland Clinic Fairview Hospital, Cleveland, OH, USA., Saxena A; Baptist Health South Florida, Miami, FL, USA.; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA., Ramamoorthy V; Baptist Health South Florida, Miami, FL, USA., Doke M; Miller School of Medicine, University of Miami, Miami, FL, USA., McGranaghan P; Semmelweis University, Budapest, Hungary. peter.mc@stud.semmelweis.hu.; Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Augustenburger Platz 1, 10117, Berlin, Germany. peter.mc@stud.semmelweis.hu., Chaparro S; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA.; Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA., Jimenez J; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. jimenej67@icloud.com.; Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA. jimenej67@icloud.com.; Advance Heart Failure and Pulmonary Hypertension, South Miami Hospital, Baptist Health South, Miami, FL, USA. jimenej67@icloud.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 07; Vol. 14 (1), pp. 27054. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1038/s41598-024-77109-y
Abstrakt: This study investigated sex differences in clinical characteristics and in-hospital outcomes of heart failure (HF) hospitalizations using the National Inpatient Sample data, 2016-2019. HF hospitalizations ≥ 41 years of age were included and stratified by sex. Study outcomes were in-hospital mortality, prolonged length of stay, mechanical ventilation, mechanical circulatory support, vasopressor use, and disposition other than home. Propensity score matched regression analysis was done to compare outcomes between sex. A total of 4,704,684 primary HF hospitalizations were included in the analysis. Of these, 2,447,784 (52.0%) were males and 2,256,899 (48.0%) were females. Regression analysis showed that females had significantly lower odds for mortality (aOR, 0.92, 95% CI: 0.89-0.94), mechanical ventilation (aOR, 0.89, 95% CI: 0.86-0.92), mechanical circulatory support (aOR, 0.54, 95% CI: 0.51-0.58), and vasopressor use (aOR, 0.71, 95% CI: 0.66-0.74), compared to males. However, the odds for prolonged length of stay (aOR, 1.05, 95% CI: 1.04-1.06) and disposition other than home (aOR, 1.32, 95% CI: 1.31-1.34) were significantly higher among females, compared to males. There were significant differences in outcomes between males and females hospitalized for HF. Further research is required to delineate how sex affects several aspects of HF, including epidemiology, risk factors, pathogenesis, and response to medications.
(© 2024. The Author(s).)
Databáze: MEDLINE
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